Methods and compositions related to targeting tumors and wounds
AssigneeBurnham Institute for Medical Research
InventorsErkki Ruoslahti, Jan Pilch
Life of this patent
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Abstract
Disclosed are compositions and methods useful for targeting tumors, sites of injury and blood clots. The compositions and methods are based on peptide sequences that selectively bind to and home to tumors, sites of injury and blood clots in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tumors, sites of injury and blood clots.
Claims36
An isolated peptide comprising an amino acid segment comprising the amino acid sequence of SEQ ID NO:
- 1 or SEQ HD NO:
- 2, an amino acid sequence at least about 90% identical to the amino acid sequence of SEQ HD NO:1 or SEQ ID NO:2, or the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2 having one or more conservative amino acid substitutions.
A method of directing a moiety to tumors, sites of injury, or sites of blood clots in a subject, comprising administering to the subject a conjugate comprising a moiety linked to a fibrin- or clotted fibronectin-binding peptide, or to a peptide that binds to another clotted plasma protein.
Dependencies are inferred from the claim text.