Human Monoclonal Antibodies Against Hendra and Nipah Viruses
AssigneesThe United States of America as represented by the Department of Health and Human Services, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsDimiter S. Dimitrov, Zhu Zhongyu, Christopher C. Broder
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Abstract
The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
Claims22
A substantially pure polypeptide comprising an antibody selectively binding a Hendra or Nipah G glycoprotein epitope, wherein said antibody includes a heavy chain CDR3 region having the amino acid sequence selected from the group consisting of SEQ ID NO:
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A substantially pure polypeptide comprising a monoclonal antibody that binds the antigen to which an antibody selectively binding a Hendra or Nipah G glycoprotein epitope binds, wherein said antibody includes a heavy chain CDR3 region having the amino acid sequence selected from the group consisting of SEQ ID NO:
- 7, SEQ ID NO:
- 23, SEQ ID NO:
- 39, SEQ ID NO:
- 55, SEQ ID NO:
- 71, SEQ ID NO:
- 87, SEQ ID NO:
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- 119, SEQ ID NO:
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- 151, SEQ ID NO:
- 167, SEQ ID NO:
- 183, SEQ ID NO:
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- 215, SEQ ID NO:
- 231, SEQ ID NO:
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- 263, SEQ ID NO:
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- 295, SEQ ID NO:
- 311, SEQ ID NO:
- 327, SEQ ID NO:
- 343, SEQ ID NO:
- 359, SEQ ID NO:
- 375, SEQ ID NO:
- 391 and SEQ ID NO:
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Dependencies are inferred from the claim text.