US 2009/0214427 A1 · Novel peptides

Abstract

Isolated peptides comprising an amino acid sequence having Formula I X1X2X3X4, I wherein X1 is an optional residue of an amino acid selected from the group of R, F, Y, S and conservative substitutes thereof; X2 stands for a residue of an amino acid selected from the group of R and A and conservative substitutes thereof; X3 is a residue of an amino acid selected from the group of F, P, G, Q, M and conservative substitutes thereof; and X4 is a residue of an amino acid selected from the group of K, F, G, P and conservative substitutes thereof. The novel peptides are capable of binding to human kallikrein 2 and of inhibiting the proteolytic activity of human kallikrein 2. They can be used in prostate cancer treatment as such or in combination with other ligands modulating the activity of factors mediating tumor growth.

Claims61

Dependent claims

An isolated peptide comprising an amino acid sequence having Formula I

X1X2X3X4, I
wherein
X1 is an optional residue of an amino acid selected from the group of R, K, F, Y, S, A and conservative substitutes thereof;
X2 stands for a residue of an amino acid selected from the group of R, K and A and conservative substitutes thereof;
X3 is a residue of an amino acid selected from the group of F, P, G, Q, M, R, K and conservative substitutes thereof;
and
X4 is a residue of an amino acid selected from the group of K, R, F, G, P and conservative substitutes thereof;
said peptide being capable of binding to human kallikrein 2 and of inhibiting the proteolytic activity of human kallikrein 2.

5 more elements

Dependencies are inferred from the claim text.

Novel peptides

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Novel peptides

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Abstract

Claims61