Human glycoprotein hormone superagonists and uses thereof
OwnerMariusz W. Szkudlinski, Bruce D. Weintraubinventors
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Abstract
The present invention provides improved methods of imaging, targeted therapy and detection and diagnostics using modified glycoprotein hormones having increased activity over wild-type hormones.
Claims75
A method of imaging cells comprising a glycoprotein hormone receptor, said method comprising administering to a subject a modified glycoprotein hormone, said modified glycoprotein hormone having at least one mutation that increases the hormone activity relative to the wild type glycoprotein hormone and detecting said modified glycoprotein hormone.
A method of delivering an agent to a cell expressing a glycoprotein receptor to a subject in need thereof, said method comprising administering to said subject an agent coupled to a modified glycoprotein hormone having at least one mutation that increases the hormone activity relative to the wild type glycoprotein hormone.
A method for the detection of an analyte that interferes with the binding of a modified glycoprotein hormone to a glycoprotein receptor in a biological sample, said method comprising (i) contacting the sample, with a modified glycoprotein hormone, said modified glycoprotein hormone having at least one mutation that increases the hormone activity relative to the wild type glycoprotein hormone and (ii) detecting a signal wherein the presence or amount of the signal detected indicates the presence or absence of an analyte that interferes with the binding of a modified glycoprotein hormone to a glycoprotein receptor.
Dependencies are inferred from the claim text.