Methods of sterilizing biological mixtures using alpha-keto acids
OwnerWilson Burgess, David Mann +2inventors
InventorsWilson Burgess, David Mann, William Drohan, Shirley Miekka
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Abstract
Methods are disclosed for sterilizing biological materials to reduce the level of one or more biological contaminants or pathogens therein, such as viruses, bacterial (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, and/or prions or similar agents responsible. These methods involve the use of alpha-keto acids in methods of sterilizing biological materials with irradiation.
Claims30
A method for reducing the level of active biological contaminants or pathogens in a tissue, said method comprising:
- (i) adding to said tissue at least one alpha-keto acid stabilizer;
- and
- (ii) irradiating said tissue with a suitable dose of gamma radiation effective to reduce the level of active biological contaminants or pathogens in said tissue.
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A method for reducing the level of active biological contaminants or pathogens in a protein sample, said method comprising:
- (i) adding to said protein sample at least one alpha-keto acid stabilizer;
- and
- (ii) irradiating said protein sample with a suitable dose of gamma radiation effective to reduce the level of active biological contaminants or pathogens in said protein sample.
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A method for reducing the level of active biological contaminants or pathogens in plasma or serum, said method comprising:
- (i) adding to said plasma or serum at least one alpha-keto acid stabilizer;
- and
- (ii) irradiating said plasma or serum with a suitable dose of gamma radiation effective to reduce the level of active biological contaminants or pathogens in said plasma or serum.
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Dependencies are inferred from the claim text.