Arterial spin labeled, segmented, interleaved 3d grase mri

A magnetic resonance imaging (MRI) method of obtaining MRI images of a patient and storing the images in physical storage media comprising:

• obtaining a first single shot arterial spin labeled (ASL) three-dimensional (3D) echo train comprising:
• first echo signals resulting from a first set of RF pulses wherein a phase encode gradient is under-sampled, and using said first echo signals to fill in a first set of lines in a first k-space;
• and
• second echo signals resulting from a second set of RF pulses that are interleaved in time with the first set of RF pulses, and using said second echo signals to fill in a second set of lines in the first k-space interleaved in k-space with said first set of lines;
• obtaining a second single shot ASL 3D echo train in essentially the same manner as the first echo train but with a shifted timing so that intrinsic T2 signal amplitude differences are opposite to those of the first echo train and the first k-space, and using the second echo train to fill in a second k-space such that for lines in matching positions in k-space high amplitude signals for the first k-space are low amplitude signals for the second k-space and vice versa;
• averaging complex data of matching k-space encoding of the first and second k-spaces to create a resulting averaged k-space;
• using the averaged k-space to generate one or more MRI images;
• and
• storing the MRI images in physical storage media.