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US 2009/0197938 A1Published application
Polyphenol Type Compounds, Compositions Containing Same and Use Thereof for Preventing or Treating Diseases Involving Abnormal Cell Proliferation
AssigneesFluofarma, Universite De Bordeaux 1
InventorsGaëlle Depierre, Stephane Quideau, Michael Jourdes, Patrick Pardon, Philippe Pourquier
Life of this patent
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Abstract
The invention concerns compounds of formula (I), wherein —XmR1 and YnR2, identical or different are present, or one of the XmR1 or YnR2 is absent and YaR2, identical or different, is present, and in that case the bond between C1 and C2 is a double bond, XmR1 and YnR2 together represent a group A and in that case the bond between C1 and A is a double bond, or their pharmaceutically acceptable salts as medicine.
Claims11
1) A compound complying with formula (I), or one of its pharmaceutically acceptable salts, as a drug:
- Formula (I)
- wherein:
- XmR1, and YnR2, identical or different, are present, or
- one of XmR1, and YnR2 is absent, and in this case the bond between C1 and C2 is a double bond,
- XmR1 and YnR2 together represent a group A and in this case the bond between C1 and A is a double bond,
- where:
- R1 and R2 represent, independent of one another, an atom of hydrogen;
- an atom of halogen;
- an alkyl, alkene or alkyne radical, containing 1 to 18 atoms of carbon, possibly substituted by one or several amino, acid, acid derivative, alkoxy, aryl or hydroxy groups;
- an aryl radical possibly substituted by one or several amino, acid, acid derivative, alkoxy, aryl or hydroxy groups;
- an arylalkyl or alkylaryl radical, possibly substituted by one or several amino, acid, acid derivative, alkoxy, aryl or hydroxy groups;
- or a nitro function;
- or R1 and R2 together form a cycle or a heterocycle, possibly substituted,
- m is a whole number chosen among 0 and 1, n is a whole number chosen among 0 and 1,
- X and Y represent independent of each other —O—, —OC(═O)—, —OC(═O)O—, —OC(═O)N—, —NR3—, —NR3C(═O)—, —NR3C(═O)O—, —NR3C(O)NR3—, —C(═O)—, —C(═O)O—, —S(O)q—, or —P(O)r—,
- q is a whole number chosen among 0, 1, 2 and 3, r is a whole number chosen from among 0, 1, 2 and 3,
- R3 represents an atom of hydrogen;
- an alkyl, alkene or alkyne radical, comprising 1 to 18 carbons, possibly substituted by one or several amino, acid, acid derivative, alkoxy, aryl or hydroxy groups;
- an aryl radical, possibly substituted by one or several amino, acid, acid derivative, alkoxy, aryl or hydroxy groups;
- an arylalkyl or alkylaryl radical possibly substituted by one or several amino, acid, acid derivative, alkoxy, aryl or hydroxy groups;
- or an alkoxy radical possibly substituted by an aryl radical;
- A represents O, S, NOR5, NR6 or CR5R6, where R5 and R6 represent, independent of each other, an atom of hydrogen, an alkyl, alkene or alkyne radical, comprising 1 to 18 atoms of carbon, possibly substituted by one or several amino, acid, acid derivative, alkoxy, aryl or hydroxy groups;
- an arylalkyl or alkylaryl radical possibly substituted by one or several amino, acid, acid derivative, alkoxy, aryl or hydroxy groups;
- or an alkoxy radical, possibly substituted by an aryl radical.
21 more elements
Dependencies are inferred from the claim text.