Treatment of Prevention of Unscheduled Bleeding in Women on Progestogen Containing Medication

A method of treating or preventing unscheduled bleeding in a woman, said unscheduled bleeding being the result of repeated administration of a hormonal composition that contains a progestogen, wherein said method comprises the administration of a RAS suppressor to the woman in an effective amount to reduce or prevent the incidence of unscheduled bleeding.

A pharmaceutical composition comprising at least 5 μg RAS suppressor, said RAS suppressor being selected from the group consisting of ACE inhibitors, angiotensin II receptor antagonists and renin inhibitors;

• a progestogen in an amount equivalent to at least 30 μg levonorgestrel;
• and pharmaceutically acceptable excipient.

A pharmaceutical kit comprising a plurality of dosage units, wherein at least one dosage unit contains a progestogen in an amount equivalent to at least 30 μg levonorgestrel;

• at least one dosage unit contains an estrogen in an amount equivalent to 5 μg ethinyl estradiol;
• and at least one dosage unit contains a RAS suppressor selected from the group consisting of ACE inhibitors, angiotensin II receptor antagonists, renin inhibitors and combinations thereof.