Biocompatible Latent Emulsifiers
AssigneeBioavailability, Inc.
InventorsSteven B. Harris, Nick Huang
Life of this patent
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Abstract
A category of biocompatible dual-purpose emulsifiers for therapeutic and/or nutritional use is disclosed. The emulsifiers have at least two functions, which depend on pH and surrounding environment. In the anhydrous environment, they serve as nonionic solvents to dissolve the hydrophobic material, such as a hydrophobic drug or nutrient. When in the alkaline aqueous environment of the small intestine, they are transformed into a biocompatible ionic emulsifier. The emulsifiers can also be used to thin the surfactant/hydrophobe mixture in self-emulsifying bases and, thus, accelerate the emulsifying speed of the base without overloading the emulsifying capacity of the emulsion base.
Claims18
A unit dosage composition for oral administration to a human for therapeutic and/or nutritional use, comprising:
- a monounsaturated free carboxylic acid and a therapeutic and/or nutritional hydrophobic agent, whereby the composition does not include a surfactant.
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A unit dosage composition for oral administration to a human for therapeutic and/or nutritional use, comprising:
- free oleic acid having a concentration of about 50% by weight of the composition and alpha tocopherol having a concentration of about 50% by weight of the composition, whereby the composition does not include a surfactant.
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A unit dosage composition for oral administration to a human for therapeutic and/or nutritional use, comprising:
- free oleic acid having a concentration of about 60% by weight of the composition, coenzyme Q10 having a concentration of about 10% by weight of the composition, orange oil having a concentration of about 10% by weight of the composition, and ethyl oleate having a concentration of about 20% by weight of the composition.
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A unit dosage composition for oral administration to a human for therapeutic and/or nutritional use, comprising:
- free oleic acid having a concentration of about 55% by weight of the composition, polysorbate 80 having a concentration of about 5% by weight of the composition, coenzyme Q10 having a concentration of about 10% by weight of the composition, orange oil having a concentration of about 10% by weight of the composition, and ethyl oleate having a concentration of about 20% by weight of the composition.
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Dependencies are inferred from the claim text.