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US 2009/0191174 A1Published application
Blood processing device and associated systems and methods
AssigneeZymeQuest, Inc.
InventorsKeith Boudreau, Dan Morgan, Mike Haley, Will Garcia De Quevedo
Life of this patent
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Abstract
The present invention is directed to an environmentally closed cell processing device, for the aseptic processing of blood cells. The device includes a continuous flow centrifuge, fluid reservoirs and fluid handling systems. Blood cells are processed by the present device, to remove their immunodominant antigens. Seroconverted cells and methods of treating subjects with these cells are also described.
Claims21
A cell processing device comprising:
- a. a continuous flow centrifuge, having a structural frame having a plurality of spaced apart structural discs and a plurality of support tubes, the centrifuge further comprising a rotor, the rotor having bearings on each end and a drive system on one end, and the rotor having a hub further comprising a port on one end and a plurality of channels therethrough each channel terminating in an aperture through the hub wall surface;
- b. a plurality of chambers disposed along the axis of the rotor, the chambers including substantially flexible processing bags and substantially flexible expressor bags;
- the processing bags having ports aligning with one or more of the channel apertures on the rotor hub, and the expressor bags having ports aligning with one or more of the channel apertures on the rotor hub;
- c. a supply module having a fluid management cassette, the fluid management cassette further comprising a network of pathways and valves, the supply module being further connected to a plurality of fluid and/or air sources, and where the valves are adapted to a system control module;
- d. a multi-lumen tube connected at one end to the supply module and at the other end to the hub on the centrifuge rotor, the tube supported by support tube rollers and a rigid arm geared to the centrifuge drive system;
- e. a plurality of supply reservoirs in communication with the supply module;
- and
- f. a system control module in electrical communication with the valves, and the centrifuge drive system, the control module having a processor, an instruction set, a fault hub system, and user defined input controls.
5 more elements
Dependencies are inferred from the claim text.