Ligand for Vesicular Acetylcholine Transporter

A method of producing a compound represented by the following formula (I):

• wherein R1 and R2 are the same or different and each is a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a C1-6 acyl group, a carboxy group, a C1-6 alkoxy group, a C1-6 alkyl group or a phenyl group, or R1 and R2 in combination optionally form a ring together with the adjacent carbon atom (the ring optionally has one or more substituents selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, a C1-6 acyl group, a carboxy group, a C1-6 alkoxy group, a C1-6 alkyl group), or a salt thereof, which comprises a step of reacting a compound of the following formula (II):
• wherein R1 and R2 are as defined for the aforementioned formula (I), or a salt thereof with 11CH3I.

A compound represented by the following formula (II):

• wherein R1 and R2 are the same or different and each is a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a C1-6 acyl group, a carboxy group, a C1-6 alkoxy group, a C1-6 alkyl group or a phenyl group, or R1 and R2 in combination optionally form a ring together with the adjacent carbon atom (the ring optionally has one or more substituents selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, a C1-6 acyl group, a carboxy group, a C1-6 alkoxy group, a C1-6 alkyl group), or a salt thereof.

A compound represented by the following formula (Ia):

• wherein R1 and R2 are the same or different and each is a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a C1-6 acyl group, a carboxy group, a C1-6 alkoxy group, a C1-6 alkyl group or a phenyl group, or R1 and R2 in combination optionally form a ring together with the adjacent carbon atom (the ring optionally has one or more substituents selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, a C1-6 acyl group, a carboxy group, a C1-6 alkoxy group, a C1-6 alkyl group), or a salt thereof.