TLR ligand and IL-1 Response-Injured Animal Model

Abstract

The present invention provides a TLR ligand/IL-1 response-impaired non-human animal model wherein IL-6 production responding to a TLR ligand/IL-1 is impaired, a method for screening a substance promoting or suppressing a response to a TLR ligand/IL-1 by using the TLR ligand/IL-1 response-impaired non-human animal model, and a method for screening a prophylactic/therapeutic agent for atopic dermatitis-like inflammatory skin disease. A non-human animal model unresponsive to a TLR ligand/IL-1 is generated wherein whole or a part of an endogenous gene of the non-human animal encoding IκB-ζ is inactivated by a gene mutation such as destruction, deletion, or substitution, a function of expressing IκB-ζ is deleted, and a IL-6 production responding to a TLR ligand and IL-1 is impaired. Moreover, the promoter or suppressor for a TLR ligand/IL-1 response and the prophylactic/therapeutic agent for atopic dermatitis-like inflammatory skin disease are screened by using the non-human animal and a test substance.

Dependencies are inferred from the claim text.