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US 2009/0157172 A1Published application
Stents with polymer-free coatings for delivering a therapeutic agent
AssigneeBoston Scientific Scrimed, Inc.
InventorsJaydeep Y. Kokate, M. Arif Iftekhar, Jan Weber
Life of this patent
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Abstract
Described herein are implantable medical devices, such as intravascular stents, for delivering therapeutic agents to a patient, and methods for making such medical devices. The medical devices comprise a substrate having at least a cavity therein and a pellet disposed in the cavity. The pellet comprises a non-polymeric material having a plurality of pores therein. A therapeutic agent is disposed in at least some of the pores.
Claims30
An implantable stent comprising:
- a. a stent sidewall structure having a surface;
- b. at least one cavity, having first and second opposing ends, disposed within the stent sidewall structure wherein the first end of the cavity comprises an opening that is in fluid communication with the stent sidewall structure surface and the second end of the cavity comprises the bottom of the cavity;
- c. at least one pellet disposed within the cavity comprising a non-polymeric material having a plurality of pores therein;
- and
- d. a therapeutic agent disposed in at least some of the pores of the pellet.
2 more elements
An implantable intravascular stent comprising:
- a. a stent sidewall structure comprising a plurality of struts each having an abluminal surface and a luminal surface,
- b. at least one cavity, having first and second opposing ends, disposed within a strut, wherein the first end of the cavity comprises an opening that is in fluid communication with the abluminal surface of the strut and the second end of the cavity comprises the bottom of the cavity;
- c. at least one pellet comprising a non-polymeric material, having a plurality of pores therein, disposed within the cavity;
- wherein the pellet has first and second opposing ends and wherein the first end of the pellet faces toward the first end of the cavity and the second end of the pellet faces toward the second end of the cavity;
- and wherein at least some of the pores have different pore sizes and the pores are arranged in a manner to form a pore size gradient in the pellet in which the pores having the largest pore size are disposed proximate the first end of the pellet;
- and
- d. an anti-restenosis agent disposed within at least some of the pores of the pellet.
4 more elements
An implantable intravascular stent comprising:
- a. a stent sidewall structure comprising a plurality of struts each having an abluminal surface and a luminal surface;
- b. at least one cavity, having first and second opposing ends, disposed within a strut, wherein the first end of the cavity comprises an opening that is in fluid communication with the abluminal surface of the strut and the second end of the cavity comprises the bottom of the cavity;
- c. at least one pellet comprising a non-polymeric material, having a plurality of pores therein, disposed within the cavity;
- wherein the pellet has first and second opposing ends and wherein the first end of the pellet faces toward the first end of the cavity and the second end of the pellet faces toward the second end of the cavity;
- and wherein the pellet comprises a first layer comprising pores having a first pore size, a second layer comprising pores having a second pore size that is smaller than the first pore size, and a third layer comprising pores having a third pore size that is smaller than the second pore size;
- and wherein the first, second and third layers are arranged in a manner to form a pore size gradient in the pellet in which the first layer is disposed proximate the first end of the pellet;
- and
- d. an anti-restenosis agent disposed within at least some of the pores of the pellet.
5 more elements
A method for making an implantable stent comprising:
- a. providing a stent having a stent sidewall structure having a surface and at least one cavity, having first and second opposing ends, disposed within the stent sidewall structure, wherein the first end of the cavity comprises an opening that is in fluid communication with the stent sidewall structure surface and the second end of the cavity comprises the bottom of the cavity;
- b. disposing at least one pellet into the cavity, wherein the pellet comprises a non-polymeric material having a plurality of pores therein;
- and wherein the pellet has first and second opposing ends, and the first end of the pellet faces toward the first end of the cavity and the second end of the pellet faces toward the second end of the cavity;
- and wherein at least some of the pores have different pore sizes and the pores are arranged in a manner to form a pore size gradient in the pellet;
- and
- c. disposing a therapeutic agent in at least some of the pores of the pellet.
3 more elements
A method for making an implantable stent comprising:
- a. providing a stent having a stent sidewall structure having a surface and at least one cavity, having first and second opposing ends, disposed within the stent sidewall structure wherein the first end of the cavity comprises an opening that is in fluid communication with the stent sidewall structure surface and the second end of the cavity comprises the bottom of the cavity;
- b. forming a pellet in the cavity, wherein the pellet has a plurality of layers and first and second opposing ends, in which the first end of the pellet faces toward the first end of the cavity and the second end of the pellet faces toward the second end of the cavity, comprising:
- (1) disposing a first solid, non-polymeric material into the cavity to form a first layer of the pellet, wherein the first layer has a plurality of pores having a first pore size;
- and
- (2) disposing a second solid, non-polymeric material into the cavity to form a second layer of the pellet disposed over the first layer, wherein the second layer has a plurality of pores having a second pore size;
- and
- c. disposing a therapeutic agent in at least some of the pores of the first and second layers.
4 more elements
Dependencies are inferred from the claim text.