Method of promoting cell proliferation and ingrowth by injury to the native tissue
AssigneeMED Institute, Inc.
InventorsClinton D. Bahler, Alan R. Leewood, Jichao Sun
Life of this patent
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Abstract
The present invention relates to methods of treating tissue of the human body, specially, methods of promoting cell proliferation and ingrowth around implantable medical devices. The methods include inserting an apparatus comprising asperities adapted to injure native tissue at a desired anchoring location, injuring the native tissue at the desired anchoring location with the apparatus to initiate an injury response in the native tissue to thereby promote cell proliferation and ingrowth; and implanting the medical device at the treatment location.
Claims23
A method of promoting cell proliferation and ingrowth around an implantable medical device, comprising:
- (a) inserting an apparatus, the apparatus comprising asperities adapted to injure native tissue at a desired anchoring location;
- (b) injuring the native tissue with the apparatus at the desired anchoring location to thereby initiate an injury response in the native tissue to promote cell proliferation and ingrowth;
- and
- (c) implanting the device at the treatment location.
A method of promoting cell proliferation and ingrowth around a stent graft, comprising:
- (a) inserting a balloon, the balloon comprising asperities adapted to injure native tissue at a desired anchoring location;
- (b) injuring the native tissue with the balloon at the desired anchoring location to thereby initiate an injury response in the native tissue to promote cell proliferation and ingrowth;
- and
- (c) implanting the stent graft at the treatment location,
- wherein the stent graft comprises extracellular matrix material.
A method of promoting cell proliferation and ingrowth around an implantable medical device to treat an aneurysm, comprising:
- (a) inserting an apparatus, the apparatus comprising asperities adapted to injure native tissue at a desired anchoring location near the aneurysm;
- (b) injuring the native tissue with the apparatus at the desired anchoring location to thereby initiate an injury response in the native tissue to thereby promote cell proliferation and ingrowth;
- and
- (c) implanting the device at an aneurysm location.
A method of promoting cell proliferation and ingrowth around a stent graft to treat an aneurysm, comprising:
- (a) inserting a balloon, the balloon comprising asperities adapted to injure native tissue at a desired anchoring location near the aneurysm;
- (b) injuring the native tissue with the balloon at the desired anchoring location to thereby initiate an injury response in the native tissue to thereby promote cell proliferation and ingrowth;
- and
- (c) implanting the stent graft at an aneurysm location,
- wherein the stent graft comprises an extracellular matrix material.
A method of promoting cell proliferation and ingrowth around an implantable medical device, comprising:
- (a) inserting an apparatus;
- (b) over-extending the apparatus to cause an injury to the native tissue at a desired anchoring location to thereby initiate an injury response in the native tissue to promote cell proliferation and ingrowth;
- and
- (c) implanting the device at the treatment location.
Dependencies are inferred from the claim text.