Degradable Endoprosthesis
AssigneeBoston Scientific Scimed, Inc.
InventorsMatthew Miller, Jan Weber
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Abstract
An endoprosthesis includes a body that has a first bioerodible metal and a surface, and a capsule formed of a second bioerodible metal disposed on the surface. The capsule includes a porous peripheral region and a drug-containing core. A method of making such an endoprosthesis is also disclosed.
Claims26
An endoprosthesis, comprising:
- a body comprising a first bioerodible metal and a surface, and
- a capsule formed of a second bioerodible metal disposed on the surface, wherein the capsule comprises at least one porous peripheral region and a drug-containing core.
A method of making an endoprosthesis, the method comprising:
- applying a sacrificial template to a surface;
- applying a plurality of metal nanoclusters over the template;
- removing the sacrificial template to form a cavity defined by the metal nanoclusters;
- and
- loading a drug into the cavity.
The method of 17, wherein the polymer particle has a size of about 10 nm to about 10 μm.
The method of 12, wherein the sacrificial template is pretreated with a polyelectrolyte to be encapsulated by a polyelectrolyte coating.
The method of 12, comprising applying the plurality of metal nanoclusters in an electrical field.
The method of 12, comprising applying the drug by soaking the endoprosthesis in a solution having the drug.
The method of 12, wherein the plurality of metal nanoclusters form a first porous coating.
The method of 23, further comprising forming a second coating over the first coating by applying a second plurality of metal nanoclusters.
The method of 24, wherein the second coating has a relatively lower porosity than the first coating and/or the second coating has a relatively smaller pore size than the first coating.
The method of 24, wherein the second coating is nonporous.
Dependencies are inferred from the claim text.