Methods, devices and compositions for controlled drug delivery to injured myocardium
AssigneeBoston Scientific Scimed, Inc.
InventorsRuth Cheng, Toby Freyman
Life of this patent
Estimating the term…
Abstract
A method for modulating remodeling of an infarct region of a myocardium, the method including the controlled local delivery of therapeutic agent(s) employing microparticles as a carrier, and devices and compositions relating thereto.
Claims26
A method for modulating remodeling of an infarct region of a myocardium, the method comprising:
- identifying an infarct region within a ventricle of the myocardium;
- infusing microparticles into a coronary artery to said infarct region, said microparticles
- comprising a bioerodable polymer composition and comprising at least one therapeutic
- agent effective for modulating remodeling of the infarct region, said microparticles having a mixed diameter range of about 1 micron to about 45 microns.
A perfusion catheter assembly for the delivery of microparticles, the perfusion catheter assembly configured and arranged to allow microparticles having a diameter of 25 microns or less to pass therethrough.
A perfusion catheter assembly for the delivery of microparticles, the perfusion catheter assembly comprising:
- a porous membrane configured to allow microparticles having a diameter of about 25 microns or less to pass therethrough.
A catheter assembly for the controlled, local delivery of a therapeutic agent to a target site within a patient, the catheter comprising at least one component having an inner surface and an outer surface, the inner surface comprising microparticles covalently bonded thereto, the microparticles comprising a bioerodable polymeric composition and at least one therapeutic agent.
Dependencies are inferred from the claim text.