Phosphine transition metal complex, method for producing the same, and antitumor agent containing the same
AssigneeNippon Chemical Industrial Co., Ltd.
InventorsHiroaki Kodama, Keisuke Ohto, Nobuhiko Oohara, Kazuhiro Nakatsui, Yoshirou Kaneda
Life of this patent
Estimating the term…
Abstract
A phosphine transition metal complex is expressed by general formula (1): wherein A represents a groups selected from among alkylene, phenylene, and cis-vinylene; M represents an atom selected from the group consisting of gold, silver, copper, and platinum; B1 and B2 each represent a substituted or unsubstituted heterocyclic group containing a trivalent phosphorus atom forming a covalent bond with A and coordinating with M; and C represents an anionic atom.
Claims8
A phosphine transition metal complex expressed by general formula (1):
- wherein A represents a group selected from among alkylene, phenylene, and cis-vinylene;
- M represents an atom selected from the group consisting of gold, silver, copper, and platinum;
- B1 and B2 each represent a substituted or unsubstituted heterocyclic group containing a trivalent phosphorus atom forming a covalent bond with A and coordinating with M;
- and C represents an anionic atom.
A method for producing a phosphine transition metal complex expressed by general formula (1):
- wherein A represents a groups selected from among alkylene, phenylene, and cis-vinylene;
- M represents an atom selected from the group consisting of gold, silver, copper, and platinum;
- B1 and B2 each represent a substituted or unsubstituted heterocyclic group containing a trivalent phosphorus atom forming a covalent bond with A and coordinating with M;
- and C represents an anionic atom,
- the method comprising the step of allowing a salt containing a metal selected from the group consisting of gold, silver, copper, and platinum with a bisphosphine derivative expressed by general formula (3):
- B1-A-B2 (3)
- wherein A, B1, and B2 are the same as specified in general formula (1).
An antitumor agent containing a phosphine transition metal complex expressed by general formula (1):
- wherein A represents a group selected from among alkylene, phenylene, and cis-vinylene;
- M represents an atom selected from the group consisting of gold, silver, copper, and platinum;
- and B1 and B2 each represent a substituted or unsubstituted heterocyclic group containing a trivalent phosphorus atom forming a covalent bond with A and coordinating with M;
- and C represents an anionic atom.
Dependencies are inferred from the claim text.