Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid
AssigneeThe General Hospital Corporation
InventorsDavid R. Elmaleh, Alan J. Fischman, Timothy M. Shoup
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Abstract
The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6 and other sequence positions of a fatty acid backbone. These novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest.
Claims36
A radioactively labeled analog of a fatty acid that is taken up by mammalian tissue, comprising the formula:
- R—(CH2)n—Z—(CH2)mCO2H,
- wherein n is 8-22, m is 0-10, R is a CH3, aryl or a heterocyclic group, and Z is a cyclic or heterocyclic organic substituent which causes said analog to be metabolically trapped in said tissue.
-8. (canceled)
-31. (canceled)
A radioactively labeled analog of a fatty acid that is taken up by mammalian tissue, comprising the formula:
- wherein:
- A=(CH2)x, O, S
- x=1, 2, 3, 4
- cis and trans;
- R,R and S,S
- m=0-10
- n=14-8
- R=18F-phenyl or 123I-phenyl
- and wherein the cyclic or heterocyclic organic substituent —CH-A-CH— causes said analog to be metabolically trapped in said tissue.
-39. (canceled)
A radioactively labeled analog of a fatty acid that is taken up by mammalian tissue, comprising the formula:
- wherein:
- A=(CH2)y, O, S
- y=1, 2, 3, 4
- cis and trans;
- R,R and S,S
- m=0-10
- n=14-8
- p=0-6
- R═CH3
- X=radioactive label
- and wherein the cyclic or heterocyclic organic substituent —CH-A-CH— causes said analog to be metabolically trapped in said tissue.
-51. (canceled)
-117. (canceled)
-146. (canceled)
Dependencies are inferred from the claim text.