Methods for synthesizing substituted tetracycline compounds
AssigneeParatek Pharmaceuticals, Inc.
InventorsFarzaneh Seyedi, Tadeusz Warchol, Mark Grier
Life of this patent
Estimating the term…
Abstract
Methods of synthesizing substituted tetracycline compounds are provided.
Claims20
A method for synthesizing a carboxaldehyde substituted tetracycline compound comprising reacting a tetracycline reactive intermediate under appropriate conditions with carbon monoxide, a palladium catalyst, a phosphine ligand, a silane and a base, such that said carboxaldehyde substituted tetracycline compound is synthesized.
A method for synthesizing a carboxaldehyde substituted minocycline compound comprising reacting aminocycline reactive intermediate under appropriate conditions with carbon monoxide, a palladium catalyst, a silane and a base, such that said carboxaldehyde substituted minocycline compound is synthesized.
Dependencies are inferred from the claim text.