Substituted Imidazoline Compounds
AssigneeMichigan State University
InventorsJetze Tepe, James Hamby
Life of this patent
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Abstract
The invention relates to compositions comprising substituted imidazoline compounds including prodrugs, and salts thereof. In some embodiments, the invention relates to the use of these compositions as therapeutic agents, preferably for the treatment of arthritis or cancer. In further embodiments, The invention relates to the pharmaceutical compositions with effective amounts of substituted imidazoline compounds disclosed herein that function as agonist or antagonists of the genetic expression or interactions with transcription factor NF-κB.
Claims17
A compound selected from the group consisting of:
- or salts thereof.
A substituted or unsubstituted compound having the following formula:
- or salts thereof wherein:
- X is ═O, or two hydrogen atoms each bound by single bonds to the adjacent carbon atom;
- and
- Y is amino, substituted amino, alkylamino, substituted alkyl amino, alkyloxy, substituted alkyloxy, arylalkyloxy, or substituted arylalkyloxy.
A substituted or unsubstituted compound having the following formula:
- or salts thereof;
- wherein Y is azido, amino, substituted amino, alkylamino, or substituted alkylamino.
A compound comprising a substituted or unsubstituted compound having the following formula:
- or salts thereof;
- wherein R1, R2, R3, and R4 are the same or differently and independently alkyl, substituted alkyl, aryl, or substituted aryl.
A salt of a compound having the following formula:
- wherein R1, R2, R3, and R4 are the same or differently and independently at each occurrence alkyl, substituted alkyl, aryl, or substituted aryl;
- and
- An is an anion.
A salt of a compound selected from the group consisting of:
- wherein R1, R2, R3, and R4 are the same or differently and independently at each occurrence alkyl, substituted alkyl, aryl, or substituted aryl, and Cat+ is a cation.
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.