Novel Compounds and Methods for Forming Taxanes and Using the Same

A method for use in producing taxanes, taxane analogs, and derivatives thereof, comprising the step of reacting a first compound of the general formula:

• with a second compound of the general structure:
• to give a third compound of the general formula:
• wherein:
• X is a halogen or OR4;
• X1 is either R1R2;
• R1P1;
• R2P1;
• or P1P1
• X2 is a substituted or unsubstituted:
• alkyl, alkenyl, aryl, aralkyl, or acyl;
• X3 is either R1;
• R2;
• or P2;
• R1 and R2 are independently H or substituted or unsubstituted:
• alkyl alkenyl, aryl, aralkyl, or acyl;
• R4 is a substituted or unsubstituted:
• alkenyl, aryl, aralkyl, acyl, alkoxy carbonyl or aryloxy carbonyl, aroyl or alkali metal;
• P1 is an amine protecting group;
• P2 is a hydroxyl protecting group;
• and
• E1, E2 and the carbon to which they are attached define a tetracyclic taxane nucleus.