Methods of preparing aripiprazole crystalline forms
OwnerJudith Aronhime, Ben-Zion Dolitzky +4inventors
InventorsJudith Aronhime, Ben-Zion Dolitzky, Eran Luvchick, Jean Hildesheim, Hagit Eisen-Nevo, Reuven Izsak
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Abstract
The invention encompasses aripiprazole crystalline forms, methods of preparing the same, and pharmaceutical compositions having aripiprazole crystalline forms.
Claims24
A method of preparing Form II by slurrying crystalline Compound 2 in acetone until Form II is formed.
A method of preparing at least one of crystalline Compound 1, crystalline Compound 2, Form D, Form I, Form II, Form VI, Form VIII, Form X, Form XI, or Form XII comprising:
- dissolving aripiprazole in a solvent to form a mixture, heating the mixture to between about 40° C. and about 132° C.;
- cooling the mixture until at least one of aripiprazole crystalline compound 1, crystalline compound 2, crystalline Form I, II, VI, VIII, X, XI, or XII precipitates;
- and
- collecting the aripiprazole.
A method of preparing crystalline Compound 2, comprising:
- dissolving aripiprazole in a solvent to form a mixture, heating the mixture to about 40° C. to about 132° C., cooling the mixture until crystalline compound 2 precipitates, and collecting the precipitated crystalline compound 2.
A method of preparing at least one of aripiprazole crystalline compound 1, crystalline compound 2, crystalline form D, II, XII or XIX, comprising:
- dissolving aripiprazole in a solvent to form a mixture, heating the mixture to the solvent's boiling point until aripiprazole dissolves, cooling the mixture, adding a co-solvent to the mixture of aripiprazole and solvent until at least one of aripiprazole crystalline compound 1, crystalline compound 2, crystalline Form D, II, XII, or XIX precipitates, and collecting the aripiprazole.
A method of preparing aripiprazole crystalline form II comprising:
- providing aripiprazole crystalline compound 1;
- and drying the aripiprazole to obtain aripiprazole crystalline form II.
Dependencies are inferred from the claim text.