Preparations containing amino acids and orotic acid

A method for producing amino acid orotate amides comprising at least the steps of:

• mixing at least equivalent molar amounts of a thionyl halide with orotic acid to form an acyl halide;
• said acyl halide then being added to a dichloromethane suspension of an amino acid in the presence of a 4-dimethyl-aminopyridine;
• and
• isolating and purifying the resulting amino acid orotate amide.

A method for producing amino acid orotate amides comprising at least the steps of:

• reacting an amino acid with N,N′-diisopropyl-O-benzylisourea to form a benzyl protected amino acid;
• isolating said benzyl protected amino acid;
• reacting an activated orotic acid with the benzyl protected amino acid to form a benzyl protected amino acid orotate amide;
• isolating and purifying said benzyl protected amino acid orotate amide;
• removing the benzyl protecting group from said benzyl protected amino acid orotate amide;
• and
• isolating and purifying the deprotected amino acid orotate amide.