N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, preparation thereof and therapeutic use thereof

A compound of the formula (I):

• wherein:
• X1 is selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, cyano, C(O)NR1R2, nitro, C1-C6-thioalkyl, —S(O)-C1-C6-alkyl, —S(O)2-C1-C6-alkyl, SO2NR1R2, aryl-C1-C6-alkylene, aryl and heteroaryl;
• wherein the aryl and heteroaryl are optionally being substituted by one or more substituents chosen from halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, nitro or cyano group;
• X2 is selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxy, C3-C7-cycloalkyl-C1-C6-alkylene-O—, C1C6-fluoroalkoxy, cyano, C(O)NR1R2, C1-C6-thioalkyl, —S(O)-C1-C6-alkyl, —S(O)2-C1-C6-alkyl, SO2NR1R2, aryl-C1-C6-alkylene, aryl and heteroaryl;
• wherein the aryl and heteroaryl optionally being substituted by one or more substituents chosen from halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, nitro or cyano group;
• X3 and X4 represent, independently of one another, hydrogen, halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxy, C3-C7-cycloalkyl-C1-C6-alkylene-O—, C1-C6-fluoroalkoxy, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6-thioalkyl, —S(O)-C1-C6-alkyl, —S(O)2-C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, aryl-C1-C6-alkylene, aryl or heteroaryl, the aryl and heteroaryl optionally being substituted by one or more substituents chosen from halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, nitro or cyano group;
• Z1, Z2, Z3 and Z4 represent, independently of one another, nitrogen or a C(R6) group, wherein at least one of said group is nitrogen and at least one of said group is a C(R6) group;
• and wherein the nitrogen atom or one of the nitrogen atoms present in the ring, defined as nitrogen of position 1, optionally being substituted by R7 when the carbon atom in the 2 or 4 position with respect to this reference nitrogen is substituted by an oxo or a thio group;
• n is equal to 0, 1, 2 or 3;
• Y is selected from the group consisting of aryl and heteroaryl both of which are optionally substituted by one or more groups chosen from halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, hydroxy, C1-C6-alkoxy, C3-C7-cycloalkyl-C1-C6-alkylene-O—, C1-C6-fluoroalkoxy, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6-thioalkyl, thiol, —S(O)-C1-C6-alkyl, —S(O)2-C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, aryl-C1-C6-alkylene or aryl group, the aryl and the aryl-C1-C6-alkylene optionally being substituted by one or more substituents chosen from halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, nitro or cyano group;
• Ra and Rb represent, independently of one another, hydrogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, hydroxy, C1-C6-alkoxy, C3-C7-cycloalkyl-C1-C6-alkylene-O—, C1-C6-fluoroalkoxy, aryl or heteroaryl group, it being possible for Ra and Rb optionally to be substituted by one or more Rc groups which are identical to or different from one another;
• Rc is selected from the group consisting of halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C3-C7-cycloalkyl-C1-C6-alkylene-O—, C1-C6-fluoroalkoxy, C1-C6-thioalkyl, —S(O)-C1-C6-alkyl, —S(O)2-C1-C6-alkyl, cyano, C(O)NR1R2, NR1R2, S(O)NR1R2, NR3COR4, NR3SO2R5, OC(O)NR1R2, NR3COOR4, NR3CONR1R2, hydroxy, thiol, oxo, thio, aryl-C1-C6-alkylene, aryl and heteroaryl;
• wherein the aryl and the heteroaryl optionally being substituted by one or more substituents chosen from halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxy, nitro or cyano group;
• R1 and R2 represent, independently of one another, hydrogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, aryl-C1-C6-alkylene or aryl group;
• or R1 and R2 together form, with the nitrogen atom which carries them, an azetidinyl, pyrrolidinyl, piperidinyl, azepinyl, morpholinyl, thiomorpholinyl, piperazinyl or homopiperazinyl group, said group optionally being substituted by a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, aryl-C1-C6-alkylene, aryl or heteroaryl group;
• R3 and R4 represent, independently of one another, hydrogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, aryl-C1-C6-alkylene, aryl or heteroaryl group;
• R5 represents C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, aryl-C1-C6-alkylene, aryl or heteroaryl group;
• R6 represents hydrogen, halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxy, C3-C7-cycloalkyl-C1-C6-alkylene-O—, C1-C6-fluoroalkoxy, C1-C6-thioalkyl, —S(O)-C1-C6-alkyl, —S(O)2-C1-C6-alkyl, aryl, aryl-C1-C6-alkylene, heteroaryl, hydroxy, thiol, oxo or thio group;
• and
• R7 represents hydrogen, C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C3-C7-cycloalkyl-C1-C6-alkylene-O—, C1-C6-fluoroalkoxyl, aryl, aryl-C1-C6-alkylene or heteroaryl group;
• it being possible for the nitrogen atom or atoms of the compound of general formula (I) to be in the oxidized form;
• or a salt thereof, or a hydrate or a solvate thereof.