Cycloalkane Carboxamide Derivatives and Production Process of Same
AssigneeSeikagaku Corporation
InventorsNobuo Kobayashi, Tsuneo Koji, Hisatomo Kunii, Mizuho Kataoka
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Abstract
Novel cycloalkane carboxamide derivatives having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkane carboxamide derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof: (wherein R1 and R2 represent (substituted) alkyl groups, (substituted) alkenyl groups, (substituted) alkynyl groups, (substituted) aromatic hydrocarbon groups or (substituted) heterocyclic groups, ring A represents an alkylidene group having 5 to 7 carbon atoms, and ring B represents a formyl group or a hydroxymethyl group).
Claims11
A cycloalkane carboxamide derivative represented by formula (I):
- [wherein R1 represents a substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted or unsubstituted aromatic hydrocarbon group, substituted or unsubstituted heterocyclic group, group represented by R4O—, group represented by R5S-(wherein R4 and R5 respectively and independently represent a substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted or unsubstituted aromatic hydrocarbon group, or substituted or unsubstituted heterocyclic group), or group represented by R6(R7)N-(wherein R6 and R7 respectively and independently represent a hydrogen atom, substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted or unsubstituted aromatic hydrocarbon group or substituted or unsubstituted heterocyclic group, furthermore R6 and R7 may together form a ring);
- R2 represents a substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted or unsubstituted aromatic hydrocarbon group, or substituted or unsubstituted heterocyclic group;
- ring A represents a cyclic alkylidene group having 5, 6 or 7 carbon atoms;
- and B represents a formyl group or hydroxymethyl group;
- provided that in the case B is a formyl group, R2 is not a 2-carboxyethyl group]
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.