Biomolecule labeling reactants based on azacycloalkanes and conjugates derived thereof

A labeling reactant of formula (I)

• wherein
• Ar is selected from the group consisting of phenyl, pyrenyl, anthracenyl and naphtyl;
• A is a linker, formed from one to ten moieties, each moiety being selected from the group consisting of phenylene, alkyl containing 1-12 carbon atoms, ethenediyl (—C≡C—), ethenediyl (—C═C—);
• ether (—O—), thioether (—S—), amide (—CO—NH— and —NH—CO— and —CO—NR4 and —NR4—CO—), carbonyl (—CO—), ester (—COO— and —OOC—), disulfide (—SS—), diaza (—N═N—) or a tertiary amine (—NR4—), where R4 represents an alkyl containing less than 5 carbon atoms;
• R1 and R2, same or different, are either protecting groups or a radical of acetic acid, acetate or acetate ion or a radical of
• wherein R3 is carboxylic acid, carboxylate ion, or an ester and X2 is selected from the group consisting of furyl, trimethoxyphenyl and phenylethynyl, where the phenyl is substituted or unsubstituted or X2 is not present;
• X is a group for conjugation of the said labeling reactant to a biospecific binding reactant;
• M is a metal or is not present;
• the indexes n, which are same or different, are 1 or 2;
• m is 1 or 2;
• z is 2 or 3.