Random copolymers of oxazoline
AssigneeJapan Science and Technology Agency
InventorsKazunori Kataoka, Yuichi Yamasaki, Joon-Sik Park
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Abstract
The invention provides approximately monodispersible random copolymers obtained from monomeric mixtures of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline, production method thereof and 2-isopropyl-2-oxazoline homopolymer obtained by using special initiator. Such polymers exhibit temperature-responsiveness in an aqueous solution within a broad temperature range, and are useful materials in the technical fields of surface chemistry and biomaterials.
Claims12
A random copolymer represented by the following formula (A):
- in the formula, In stands for a residue of a cationic polymerization initiator, NP stands for a residue of a nucleophilic agent, and m and n are integers of 5-10,000 independently of each other, m+n being an interger of 10-20,000 and m:n being, in terms of molar ratio, 1:99-99:1.
A production method of a random copolymer represented by the formula (A):
- (in the formula, In stands for a residue of a cationic polymerization initiator, NP stands for a residue of a nucleophilic agent, and m and n are integers of 5-10,000 independently of each other, m+n being an interger of 10-20,000 and m:n being, in terms of molar ratio, 1:99-99:1)
- which comprises a step of ring-opening polymerizing a monomeric mixture of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline at a molar ratio of 1:99-99:1 in an inert solvent at 30° C. -50° C. in the presence of a cationic polymerization initiator, a step of reacting the resultant random copolymer with a nucleophilic agent, and, where necessary, a step of isolating the formed polymer.
An assembly of molecules of a random copolymer represented by the following formula (A), which has a degree of dispersion (Mw/Mn) not higher than 1.2:
- in the formula, In stands for a residue of a cationic polymerization initiator, NP stands for a residue of a nucleophilic agent, and m and n are integers of 5-10,000 independently of each other, m+n being an interger of 10-20,000 and m:n being, in terms of molar ratio, 1:99-99:1.
A homopolymer represented by the following formula
- in the formula, R3 stands for hydrogen or C1-5 alkyl, m stands for an integer of 1-20, and n stands for an integer of 5-10,000.
Dependencies are inferred from the claim text.