Polymers comprising thioester bonds
AssigneeDsm IP Assets B.V.
InventorsAylvin Jorge Angelo Athanasius Dias, Mark Johannes Boerakker, Atze Jan Nijenhuis
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Abstract
This invention is in the field of polymer chemistry. More in particular it provides a method to produce polymers such as block copolymers or cross-linked networks that are suitable for medical applications. The invention also provides degradable materials that may degrade completely when used in the human or animal body, minimizing residual components that may be toxic or otherwise undesirable.
Claims16
Method of making a polymer comprising at least two thioester bonds via an addition reaction, said method comprising the steps of:
- a. forming a composition by admixing a component X comprising at least one ethylenically unsaturated group with a component Y comprising at least two thioic acid group, wherein X and/or Y is a monomer, oligomer or a polymer and
- b. allowing the components to form at least two thioester bonds.
A block copolymer comprising at least one degradable block wherein the individual blocks are linked together by thioester bonds according to formula 2 or formula 3.
- and wherein W1, W2 and W3 are selected from the group consisting of C, H, O, N, S, P, alkyl, aryl, ester and ether.
A polymer comprising a fragment according to formula 4, wherein W1, W2 and W3 are selected from the group consisting of C, H, O, N, S, P, alkyl, aryl, ester and ether, and wherein R may be a monomer, oligomer or polymer, and wherein m and n are integers, the sum of which indicates the number of thioester linkers connected to R and wherein the sum of m and n is at least 2.
Dependencies are inferred from the claim text.