Fab I and inhibition of apicomplexan parasites
OwnerRima McLeod, Michael Kirisits +10inventors
InventorsRima McLeod, Michael Kirisits, Dennis Kyle, Douglas G. Mack, Wilbur Milhous, Stephen Muench, Ernest J. Mui, Sean Prigge, John Rafferty, David Rice, Craig W. Roberts, Benjamin Samuel
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Abstract
Discovery and characterization of an apicomplexan Fab I gene and encoded enzyme and discovery of the triclosan as a lead compound, provide means to rationally design novel inhibitory compositions useful for prevention and treatment of apicomplexan related diseases.
Claims9
A molecule of the fab I enzyme having the amino acid sequence of the Fab I enzyme in Plasmodium falcipamm, as shown in FIG. 1.
Use of the amino acid sequence information from apicomplexan Fab I as a target to develop inhibitors and antimicrobal agents disease causing agents.
A novel recombinant protein with an amino acid sequence substantially similar to that of Plasmodium falcipamm shown FIG. 1.
Use of the information on the mRNA sequence corresponding to the amino acid sequence of apicomplexan Fab I to develop iRNA which will complete for the FAB I mRNA.
Use of the plasmid targeting sequence of the Plasmodium falcipamm Fab I amino acid sequence according to FIG. 1, to design antimicrobial agents and inhibitors of apicomplexan growth and survival.
Use of triclosan to inhibit apicomplexan growth and survival.
Dependencies are inferred from the claim text.