Method of treating asthma, allergic rhinitis, and skin disorders

A method for the treatment of asthma, allergic rhinitis, or a skin disorder in a mammal, which comprises administering to the mammal a composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound of formula I:

• wherein
• R1 is C2H5, CO2R, CONR2R2, CH2OR4, 1,3,4-oxadiazole-2-yl, or CH2NR5R6, where:
• R is H, C1-6 straight chain or branched alkyl, C3-6 cycloalkyl, or phenyl, or R1 is a carboxylate salt of formula CO2−R+, where R+ is Li+, Na+, K+, or an ammonium moiety of formula +NR10R11R12R13;
• R2, R3 are independently H, C1-6 alkyl, C3-6 cycloalkyl, benzyl, phenyl, OH, OCH3, or OC2H5, provided that at most only one of R2, R3 is OH, OCH3, or OC2H5;
• R4 is H, C(O)R14, C1-6 alkyl, C3-6 cycloalkyl, benzyl, or phenyl;
• R5, R6 are independently H, C(O)R14, C1-6 alkyl, C3-6 cycloalkyl, benzyl, phenyl, OH, OCH3, or OC2H5, provided that at most only one of R2, R3 is OH, OCH3, or OC2H5;
• R7, R8, and R9 are independently H, CH3, C2H5, C(O)R14, or CO2R15;
• or R7 and R8 or R8 and R9 together constitute a carbonyl group (C═O), thus forming a cyclic carbonate;
• or OR8R1 together form a cyclic ester;
• R10-R13 are independently H or C1-6 alkyl, group optionally bearing an OH or OCH3 substituent;
• R14 is H, C1-6 alkyl, C3-6 cycloalkyl, benzyl, or phenyl;
• and
• R15 is C1-6 alkyl, C3-6 cycloalkyl, benzyl, or phenyl;
• wherein the skin disorder is selected from the group consisting of allergic dermatitis;
• contact hypersensitivity;
• urticaria;
• rosacea;
• and psoriasis.