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AssigneeAjinomoto Co., Inc.
InventorsYuji Naito, Naoto Koyama, Katsuya Suzuki, Hideaki Kihara, Yuka Ikenoue
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The present invention provides a method of improving or preventing various conditions through suppression of the expression of inflammatory cytokines based on the action mechanism of suppression of NF-κB activation. The present invention provides a composition for suppressing NF-κB activation, containing a serotonin derivative such as feruloyl serotonin (N-feruloyl serotonin) and p-coumaroyl serotonin (N-(p-coumaroyl)serotonin), a composition for suppressing the expression of VCAM-1 and/or MCP-1 via NF-κB, containing the serotonin derivative and an anti-inflammatory composition containing the serotonin derivative. The composition of the present invention can be used as a pharmaceutical agent or a food.
A method for suppressing NF-κB activation, comprising administering an effective amount of a serotonin derivative to a subject in need thereof.
A method for the treatment or prophylaxis of a disease caused by NF-κB activation, comprising administering an effective amount of a serotonin derivative to a subject in need thereof.
A method for suppressing the expression of VCAM-1 and/or MCP-1 via NF-κB, comprising administering an effective amount of a serotonin derivative to a subject in need thereof.
A method for the treatment or prophylaxis of a disease caused by the expression of VCAM-1 and/or MCP-1 via NF-κB, comprising administering an effective amount of a serotonin derivative to a subject in need thereof.
A method of treating or preventing an inflammatory disease, comprising administering an effective amount of a serotonin derivative to a subject in need thereof.
Dependencies are inferred from the claim text.