Cellular phosphorylation potential enhancing compositions preparation and use thereof
OwnerRolf Bunqerinventor
Life of this patent
Estimating the term…
Abstract
A pharmaceutical composition comprising as an active phosphorylation potential enhancing substance a pharmaceutically-acceptable salt of an alpha-keto carboxylic acid thereof alone or in combination with nicatinamide and creatine and, its use and products containing the same.
Claims15
A method for enhancing the phosphorylation potential within the cells of a mammal in order to prevent and/or ameliorate the deterioration or promote the restoration and preservation of normal cell functions comprising administering to a mammal in need thereof a pharmaceutical composition containing as an active ingredient thereof a salt of an alpha-ketocarboxylic acid having the formula R—C(0)(CO)OM wherein R is alkyl of 1 to 12 carbon atoms;
- substituted alkyl of 1 to 12 carbon atoms, cyloalkyl of 3 to 10 carbon atoms, alkenyl of 2 to 6 carbon atoms;
- alkynyl of 3 to 6 carbon atoms;
- benzyl;
- substituted benzyl (wherein the substituent is methyl, phenyl on the alpha carbon atom or the substituent is methyl, dimethyl, halo, dihalo, or ethoxy on the phenyl ring);
- adamantyl;
- phenyl;
- naphthyl;
- substituted phenyl or substituted napthyl (wherein the ring is mono-, di-, or trisubstituted and the substitutents are alkyl of 1 to 4 carbon atoms, halo, alkoxy of 1 to 4 carbon atoms, phenoxy, trihalomethyl, dimethylamino, diethylamino, and M is a cation.
A composition according to claim 14 wherein said salt of an alpha-ketocarboxylic acid is present in combination with nicatinamide, creatine and/or an amino acid.
A food product for enhancing the phosphorylation potential within the cells of a mammal in order to retard and/or ameliorate the deterioration or promote the restoration and preservation of normal cell functions thereby enhancing physical endurance or refreshment comprising a pharmaceutical composition having as an active ingredient thereof a salt of an alpha-ketocarboxylic acid having the formula R—C(0)(CO)OM wherein R is alkyl of 1 to 12 carbon atoms;
- substituted alkyl of 1 to 12 carbon atoms, cyloalkyl of 3 to 10 carbon atoms, alkenyl of 2 to 6 carbon atoms;
- alkynyl of 3 to 6 carbon atoms;
- benzyl;
- substituted benzyl (wherein the substituent is methyl, phenyl on the alpha carbon atom or the substituent is methyl, dimethyl, halo, dihalo, or ethoxy on the phenyl ring);
- adamantyl;
- phenyl;
- naphthyl;
- substituted phenyl or substituted napthyl (wherein the ring is mono-, di-, or trisubstituted and the substitutents are alkyl of 1 to 4 carbon atoms, halo, alkoxy of 1 to 4 carbon atoms, phenoxy, trihalomethyl, dimethylamino, diethylamino, and M is a cation.
Dependencies are inferred from the claim text.