US 2009/0156646 A1Published application

Pyridylphenol compound and use thereof

AssigneeTakeda Pharmaceutical Company Limited

InventorsSatoshi Sasaki, Atsuo Baba

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Abstract

The present invention provides a compound which has metastin receptor antagonist activity and is useful for preventing and treating hormone-dependent cancer, benign prostatomegaly, endometriosis, precocious puberty, uterine myoma or the like. More specifically, the present invention provides a compound, represented by the formula: or a salt thereof, a prodrug thereof, and a pharmaceutical agent containing the same; wherein Ring A represents a 5- to 8-membered homocyclic or heterocyclic group optionally having a substituent other than formula —X-R1 wherein X represents a bond or a spacer, and R1 represents optionally substituted amino or an optionally substituted nitrogen-containing heterocyclic group; Ring B represents an optionally substituted benzene ring; R2 represents an optionally substituted homocyclic or heterocyclic group; and R3 and R4 independently represent a hydrogen atom, cyano, acyl or an optionally substituted hydrocarbon group.

Claims22

Dependent claims

A compound represented by the formula:

or a salt thereof, wherein
Ring A represents a 5- to 8-membered homocyclic or heterocyclic group optionally having a substituent other than a group represented by formula —X-R1 wherein X represents a bond or a spacer, and R1 represents optionally substituted amino or an optionally substituted nitrogen-containing heterocyclic group;
and the group represented by formula —X-R1 may be located at any position on Ring A;
Ring B represents a benzene ring optionally having a substituent other than hydroxy;
R2 represents an optionally substituted homocyclic or heterocyclic group;
and
R3 and R4 independently represent a hydrogen atom, cyano, acyl or an optionally substituted hydrocarbon group;
with proviso that the compound or the salt thereof excludes
N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)pyridin-2-yl]thiophene-2-carboxamide, [(3-{3-cyano-6-(2-hydroxyphenyl)-2-[(2-thienylcarbonyl)amino]pyridin-4-yl}phenyl)amino] (oxo)acetic acid ethylester,
N-(3-cyano-6-(2-hydroxyphenyl)-4-{3-[methoxyacetyl)amino]phenyl}pyridin-2-yl)thiophene-2-carboxamide, N-(3-{3-cyano-6-(2-hydroxyphenyl)-2-[(2-thienylcarbonyl)amino]pyridin-4-yl}phenyl)-5-oxotetrahydrofuran-2-carboxamide,
N-[3-(cyano-6-(2-hydroxyphenyl)-4-(3-{[(5-oxotetrahydrofuran-2-yl)carbonyl]amino}phenyl)pyridin-2-yl]isoxazole-5-carboxamide, and
N-[3-cyano-6-(2-hydroxyphenyl)-4-(3-{[(5-oxotetrahydrofuran-2-yl)carbonyl]amino}phenyl)pyridin-2-yl]-2-furanamide).

9 more elements

Dependencies are inferred from the claim text.