5-Membered heterocyclic compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsHaruyuki Nishida, Yasuyoshi Arikawa, Keizo Hirase
Life of this patent
Estimating the term…
Abstract
The present invention provides 5-membered heterocycle compounds represented by the following general formula (I): The present compounds have a superior acid secretion inhibitory effect, and shows an antiulcer activity and the like.
Claims22
A compound represented by the formula (I):
- wherein
- ring A is a saturated or unsaturated 5-membered heterocycle containing, as a ring-constituting atom besides carbon atoms, at least one heteroatom selected from a nitrogen atom, an oxygen atom and a sulfur atom, the ring-constituting atoms X1 and X2 are the same or different and each is a carbon atom or a nitrogen atom, the ring-constituting atoms X3 and X4 are the same or different and each is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom (provided that a pyrrole ring wherein X1 is a nitrogen atom is excluded from ring A), and when the ring-constituting atoms X3 and X4 are the same or different and each is a carbon atom or a nitrogen atom, each ring-constituting atom optionally has substituent(s) selected from an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted mercapto group, an optionally substituted amino group, a halogen atom, a cyano group and a nitro group;
- ring B is a cyclic group containing X5 and X6 as ring-constituting atoms, X5 is a carbon atom or a nitrogen atom, and X6 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom;
- R1 is a cyclic group optionally having substituent(s);
- R2 is a substituent that X6 optionally has when X6 is a carbon atom or a nitrogen atom;
- R3 is an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted mercapto group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group;
- R4 and R5 are the same or different and each is a hydrogen atom or an alkyl group, or R4 and R5 optionally form, together with the adjacent nitrogen atom, an optionally substituted nitrogen-containing hererocycle;
- m is 0 or 1, provided that ring B is an aryl group or a heteroaryl group, then m should be 1;
- and
- n is an integer of 0 to 3,
- or a salt thereof.
A compound represented by the formula (I)
- wherein
- ring A is a saturated or unsaturated 5-membered heterocycle containing, as a ring-constituting atom besides carbon atoms, at least one heteroatom selected from a nitrogen atom, an oxygen atom and a sulfur atom, the ring-constituting atoms X1 and X2 are the same or different and each is a carbon atom or a nitrogen atom, the ring-constituting atoms X3 and X4 are the same or different and each is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom (provided that a pyrrole ring wherein X1 is a nitrogen atom is excluded from ring A), and when the ring-constituting atoms X3 and X4 are the same or different and each is a carbon atom or a nitrogen atom, each ring-constituting atom optionally has substituent(s) selected from an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted mercapto group, an optionally substituted amino group, a halogen atom, a cyano group and a nitro group;
- ring B is a cyclic group containing X5 and X6 as ring-constituting atoms, X5 is a carbon atom or a nitrogen atom, and X6 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom;
- R1 is a cyclic group optionally having substituent(s);
- R2 is a substituent that X6 optionally has when X6 is a carbon atom or a nitrogen atom;
- R3 is an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted mercapto group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group;
- R4 and R5 are the same or different and each is a hydrogen atom or an alkyl group;
- m is 0 or 1, provided that ring B is an aryl group or a heteroaryl group, then m should be 1;
- and
- n is an integer of 0 to 3,
- or a salt thereof.
1-[4-(2-Fluoropyridin-3-yl)-5-(pyridin-3-ylsulfonyl)thiophen-2-yl]-N-methylmethanamine or a salt thereof.
1-[5-(2-Fluoropyridin-3-yl)-4-(pyridin-3-ylsulfonyl)thiophen-2-yl]-N-methylmethanamine or a salt thereof.
1-[1-(2-Fluoropyridin-3-yl)-5-(phenylsulfonyl)-1H-pyrazol-3-yl]-N-methylmethanamine or a salt thereof.
1-[1-(2-Fluorophenyl)-5-(pyridin-3-ylsulfonyl)-1H-pyrazol-3-yl]-N-methylmethanamine or a salt thereof.
1-[1-(2-Chlorophenyl)-5-(pyridin-3-ylsulfonyl)-1H-pyrazol-3-yl]-N-methylmethanamine or a salt thereof.
1-{1-(2-Chlorophenyl)-5-[(6-methylpyridin-3-yl)sulfonyl]-1H-pyrazol-3-yl}-N-methylmethanamine or a salt thereof.
1-[1-(2,3-Difluorophenyl)-5-(pyridin-3-ylsulfonyl)-1H-pyrazol-3-yl]-N-methylmethanamine or a salt thereof.
1-{1-(2,3-Difluorophenyl)-5-[(6-methylpyridin-3-yl)sulfonyl]-1H-pyrazol-3-yl}-N-methylmethanamine or a salt thereof.
Dependencies are inferred from the claim text.