Inhibition of cyclooxygenase-2 activity
AssigneesCelgene Corporation, Cornell Research Foundation, Inc.
InventorsAndrew J. Dannenberg, George Muller
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Abstract
The present invention provides new methods for inhibiting the activity of the enzyme cycloxygenase-2 (or COX-2). Inhibitors of COX-2 are known to be useful anti-inflammatory, analgesic and anti-angiogenic agents. The compounds in the present case are heterocyclic substituted 4-aminoglutarimides. Methods of using the compounds to inhibit prostaglandin synthesis are claimed.
Claims8
1-15. (canceled)
A method for inhibiting the activity of cyclooxygenase-2 in a human, comprising administering to the human a therapeutically effective amount of 3-succimido-2,6-dioxopiperidine or 1-allyl-3-succimido-2,6-dioxopiperidine.
Dependencies are inferred from the claim text.