Uses of nordihydroguaiaretic acid (NDGA) and derivatives thereof in preventing transmission of sexually transmitted diseases
OwnerNiharika Khannainventor
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Abstract
Provided herein are methods for inhibiting proliferation of a microbe associated with a sexually transmitted disease (STD) or infection and for preventing transmission of one or more sexually transmitted diseases in a subject at-risk for acquiring the same, including an HIV positive subject at risk for acquiring another sexually transmitted disease. The methods comprise contacting a microbe or cell thereof associated with the STD or administering to the subject nordihydroguaiaretic acid or a derivative or analog thereof. In HIV positive at-risk subjects one or more anti-retroviral drugs are co-administered.
Claims20
A method for inhibiting proliferation of a microbe associated with a sexually transmitted disease or infection, comprising:
- contacting the microbe or a microbial cell thereof with an amount of one or more microbicidal compounds effective to inhibit an activity required for proliferation thereof, said compounds having a structural formula
- wherein R1-R4 are independently H, C1-C2alkyl, C(═O)(C1-C2alkyl), —C(═O)CH2NH2, —C(═O)CH2N(H)(C1-C2alkyl)2, or —C1-C2alkyl-N-piperidinyl, or a pharmacologically effective salt or hydrate thereof.
A method for preventing transmission of one or more sexually transmitted diseases in a subject at-risk for acquiring the same, comprising:
- administering one or more of a microbicidal compound to the subject, said compound(s) having a structural formula
- wherein R1-R4 are independently H, C1-C2alkyl, C(═O)(C1-C2alkyl), —C(═O)CH2NH2, —C(═O)CH2N(H)(C1-C2alkyl)2, or —C1-C2alkyl-N-piperidinyl, or a pharmacologically effective salt or hydrate thereof.
A method for preventing transmission of one or more sexually transmitted diseases in an HIV positive subject at-risk for acquiring the same, comprising:
- co-administering one or more of a microbicidal compound to the subject, said compound(s) having a structural formula
- wherein R1-R4 are independently H, C1-C2alkyl, C(═O)(C1-C2alkyl), —C(═O)CH2NH2, —C(═O)CH2N(H)(C1-C2alkyl)2, or —C1-C2alkyl-N-piperidinyl, or a pharmacologically effective salt or hydrate thereof and one or more anti-retroviral drugs.
Dependencies are inferred from the claim text.