N-aryl piperidine substituted biphenylcarboxamides

A compound of formula (I)

• the N-oxides, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein
• R1 is hydrogen, C1-4alkyl, halo, or polyhaloC1-4alkyl;
• R2 is hydrogen, C1-4alkyl, halo, or polyhaloC1-4alkyl;
• R3 is hydrogen or C1-4alkyl;
• R4 is hydrogen, C1-4alkyl, or halo;
• n is an integer zero or 1;
• X1 and X2 are either both carbon, X1 is carbon and X2 is nitrogen, or X1 is nitrogen and X2 is carbon;
• X3 is carbon, or nitrogen provided that only one of X1 or X2 is nitrogen;
• Y is O or NR6 wherein R6 is hydrogen or C1-4alkyl;
• and
• R5 is hydrogen;
• C1-6alkyl optionally substituted with C1-4alkyloxy, cyano, polyhaloC1-4alkyl, or aryl;
• C2-6alkenyl optionally substituted with aryl;
• C3-6alkynyl optionally substituted with aryl;
• aryl or heteroaryl;
• aryl is phenyl;
• phenyl substituted with one, two or three substituents each independently selected from nitro, azido, cyano, halo, hydroxy, C1-6alkyl, C3-6cycloalkyl, C1-4alkyloxy, polyhaloC1-6alkyl, amino, mono- or di(C1-6alkyl)amino;
• heteroaryl is pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, triazolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, furanyl, or thienyl;
• and optionally substituted with one, two or three substituents each independently selected from nitro, azido, cyano, halo, hydroxy, C1-6alkyl, C3-6cycloalkyl, C1-4alkyloxy, polyhaloC1-4alkyl, amino, mono- or di(C1-6alkyl)amino.