Mammalian hedgehog signaling modulators

A composition comprising (1) a mammalian Hedgehog signaling inhibitor or pharmaceutically acceptable salt, solvate, ester, or prodrug thereof and (2) a pharmaceutically acceptable carrier, diluent, or adjuvant,

• wherein the mammalian Hedgehog signaling inhibitor comprises a compound selected from the group consisting of:
• or a pharmaceutically acceptable salt, solvate, ester, or prodrug thereof,
• wherein R1 is hydrogen or unsubstituted or substituted, linear or branched C1-10 alkyl;
• R2 is selected from the group consisting of hydrogen, halogen, unsubstituted or substituted, linear or branched C1-10 alkyl, and C1-10 alkoxy;
• R3 is selected from the group consisting of hydrogen, halogen, and unsubstituted or substituted, linear or branched C1-10 alkyl groups;
• R4 is selected from the group consisting of hydrogen, halogen, unsubstituted or substituted, linear or branched C1-10 alkyl, and C1-10 alkoxy groups;
• R5 is selected from the group consisting of hydrogen, halogen, unsubstituted or substituted, linear or branched C1-10 alkyl groups, and N(R1)2;
• R6 is selected from the group consisting of hydrogen, halogen, unsubstituted or substituted, linear or branched C1-10 alkyl groups, N(R1)2, and C(O)R1;
• R′ is selected from the group consisting of hydrogen, halogen, unsubstituted or substituted, linear or branched C1-10 alkyl, C1-10 alkoxy, and SO2R1;
• R″ is hydrogen, halogen, unsubstituted or substituted linear or branched C1-10 alkyl, or unsubstituted or substituted aryl or heteroaryl, and
• Ar is unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl.