Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperzaine compounds

A method of treating post-traumatic stress disorder and acute stress disorder, comprising the step of administering to a patient in need thereof a therapeutic dose of a pharmaceutical composition comprising a compound having the following formula:

• where:
• (a) A2 and A3 are C or N;
• (b) R3 is hydrogen, alkyl, aralky, heteroaralkyl, alkenyl, aralkenyl, heteroaralkenyl, aryl, heteroaryl, or does not exist when A3 is N;
• (c) R6 is hydrogen, alkyl, aralkyl, heteroaralkyl, aryl or heteroaryl;
• (d) R6 is hydrogen unless R6 is alkyl, in which case R6 is hydrogen or the same alkyl as R6;
• (e) L is a linker group;
• and
• (f) B has the following formula:
• where:
• (i) R2 is hydrogen, alkyl, hydroxy, halo, alkoxy, cyano, methylthio;
• (ii) R3 is hydrogen, alkyl, hydroxy, methoxy, halo, alkoxy, perfluoroalkyl, nitro, amino, aminocarbonyl, aminosulfonyl;
• (iii) R2 and R3 can be taken together to form a 5 or 6 member aromatic or non-aromatic ring, which can contain from 0 to 3 heteroatoms selected from the group of N, O, or S;
• (iv) R4 is hydrogen, alkyl, halo, alkoxy, perfluoroalkyl, perfluoroalkoky, or nitro;
• and
• (v) R3 and R4 when taken together can form a 5 or 6 membered ring and can contain one or more heteroatoms;
• and pharmaceutically acceptable salts and esters thereof.