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US 2009/0156604 A1Published application
Fused bicyclic imidazoles
AssigneeBayer Intellectual Property GmbH
InventorsSwen HOLDER, Armin Zulch, Thomas Bar, Thomas Maier, Astrid Zimmermann, Thomas Beckers, Volker Gekeler, Hemant Joshi, Yogesh Munot, Umesh Bhise, Sunil Chavan, Sachin Shivatare, Sarvesh Patel, Vikas Gore
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Abstract
Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
Claims13
A compound of formula (I)
- wherein ring B and the imidazole to which it is fused form a ring system selected from
- wherein
- R1 is hydrogen, 1-4C-alkyl, halogen, amino, —SR2, trifluoromethyl, cyano, 3-7C-cycloalkyl, 2-4C-alkenyl, 2-4C-alkynyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, mono- or di-1-4C-alkylamino, mono- or di-1-4C-alkylaminocarbonyl, —C(NH)NH2, —C(O)NH2 or —C(O)OR10
- R2 is hydrogen, 1-4C-alkyl or 3-7C-cycloalkyl,
- R3 is hydrogen, 1-4C-alkyl or halogen,
- R4 is phenyl substituted by R5, unsubstituted phenyl, thienyl, pyridinyl, thiazolyl or oxazolyl,
- R5 is 1-4C-alkyl, halogen or 1-4C-alkoxy,
- R6 is hydrogen or 1-4C-alkyl,
- R7 is —W—Y,
- W is a monocyclic 5-membered heteroarylene comprising 1 nitrogen atom and optionally 1 or 2 further heteroatoms independently selected from oxygen, nitrogen and sulphur,
- and wherein the heteroarylene is optionally substituted by R8,
- R8 is 1-4C-alkyl or 3-7C-cycloalkyl,
- Y is phenyl or a monocyclic 5- or 6-membered heteroaryl comprising 1 nitrogen atom and optionally 1 or 2 further heteroatoms independently selected from oxygen, nitrogen, sulphur
- and wherein the heteroaryl is optionally substituted by R9,
- R9 is 1-4C-alkyl, 1-4C-alkoxy or halogen,
- R10 is hydrogen or 1-4C-alkyl,
- or a salt, particularly a pharmaceutically acceptable salt, a tautomer, or a stereoisomer of said compound, or a salt, particularly a pharmaceutically acceptable salt, of said tautomer or said stereoisomer.
14 more elements
Dependencies are inferred from the claim text.