2-aminopyridine analogs as glucokinase activators

A compound selected from the Formula

• and salts thereof, wherein:
• L is O, S, C(═O) or CHR14;
• Y is N or CR4;
• Z is N or CR3, wherein at least one of G or Z is not N;
• G is N or CR11;
• R1 is a heteroaryl ring represented by the formula
• D1 is S, O, or N;
• D2 is N or CR12;
• D3 is S, O or CR13;
• R2 is aryl, heteroaryl, saturated or partially unsaturated cycloalkyl, or saturated or partially unsaturated heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl are monocyclic or bicyclic and are optionally substituted with one or more groups independently selected from C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl, aryl, heteroaryl, F, Cl, Br, I, CF3, CN, NO2, OR6, C(═O)R6, C(═O)OR6, OC(═O)R6, O(CH2)nC(═O)OR6, O(CH2)nC(═O)NR6R7, C(═O)NR6R7, NR6R7, NR6C(═O)R7, SR6, S(O)R6, and S(O)2R6, and wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 Vn-cycloalkyl, saturated and partially unsaturated C1-C6 Vn-heterocyclyl, Vn-aryl, Vn-heteroaryl, Vn—F, Vn—Cl, Vn—Br, Vn—I, Vn—CF3, Vn—CN, Vn—OR8, Vn—C(═O)R8, Vn—C(═O)OR8, Vn—OC(═O)R8, Vn—C(═O)NR8R9, Vn—NR8R9, Vn—NR8C(═O)R9, Vn—SR8, Vn—S(O)R8, and Vn—S(O)2R8;
• R3 is H, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, saturated or partially unsaturated C3-C12 cycloalkyl, saturated or partially unsaturated C1-C12 heterocyclyl, aryl, heteroaryl, F, Cl, Br, I, CN, OR6, C(═O)R6, C(═O)OR6, OC(═O)R6, C(═O)NR6R7, OC(═O)NR6R7, OC(═S)NR6R7, NR6R7, NR6C(═O)R7, SR6, S(O)R6, S(O)2R6 or S(O)2NR6R7, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more groups independently selected from oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl, Vn-aryl, Vn-heteroaryl, Vn—F, Vn—Cl, Vn—Br, Vn—I, Vn—CF3, Vn—CN, Vn—OR8, Vn—C(═O)R8, Vn—C(═O)OR8, Vn—OC(═O)R8, Vn—C(═O)NR8R9, Vn—NR8R9, Vn—NR8C(═O)R9, Vn—SR8, Vn—S(O)R8, Vn—S(O)2R8 and Vn—S(O)2NR8R9;
• R4 is H, methyl, ethyl, F, Cl, Br, I, CF3, CHF2 or CH2F;
• R6 and R7 are independently H, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, saturated or partially unsaturated C3-C12 cycloalkyl, saturated or partially unsaturated C1-C12 heterocyclyl, Vn-aryl, or Vn-heteroaryl, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl portions are optionally substituted with one or more groups independently selected from oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl [optionally substituted with C(O)O(1-6C alkyl), (1-6C)alkyl or (1-6C alkyl)OH], Vn-aryl, Vn-heteroaryl, Vn—F, Vn—Cl, Vn—Br, Vn—I, Vn—CF3, Vn—CN, Vn—OR8, Vn—C(═O)R8, Vn—C(═O)OR8, Vn—OC(═O)R8, Vn—C(═O)NR8R9, Vn—NR8R9, Vn—NR8C(═O)R9, Vn—SR8, Vn—S(O)R8, Vn—S(O)2R8, Vn—S(O)2NR8R9, and (C1-C6 alkyl)OH;
• or R6 and R7 together with the atoms to which they are attached form a saturated or partially unsaturated heterocyclic ring, wherein said heterocyclic ring optionally comprises one or more additional ring heteroatoms independently selected from N, O or S, wherein said heterocyclic ring is optionally substituted with one or more groups independently selected from oxo, Vn—F, Vn—Cl, Vn—Br, Vn—I, Vn—OR8, Vn—C(═O)OR8, Vn—C(═O)NR8R9, Vn—NR8R9, Vn—NR8C(═O)R9, Vn—NR8C(═O)NR9R10, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 alkynyl;
• R8, R9 and R10 are independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl, aryl or heteroaryl, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more groups independently selected from oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl, Vn-aryl, Vn-heteroaryl, Vn—F, Vn—Cl, Vn—Br, Vn—I, Vn—ORa, Vn—NRaRb, Vn—C(═O)ORa, Vn—C(═O)NRaRb, and Vn—NRaC(═O)Rb,
• or R8 and R9 together with the atoms to which they are attached form a saturated or partially unsaturated heterocyclic ring, wherein said heterocyclic ring optionally comprises one or more additional ring heteroatoms independently selected from N, O or S, wherein said heterocyclic ring is optionally substituted with one or more groups independently selected from oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Vn—F, Vn—Cl, Vn—Br, Vn—I, Vn—ORa, and Vn—CN,
• or R9 and R10 together with the atoms to which they are attached form a saturated or partially unsaturated heterocyclic ring, wherein said heterocyclic ring optionally comprises one or more additional ring heteroatoms independently selected from N, O or S, wherein said heterocyclic ring is optionally substituted with one or more groups independently selected from oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Vn—F, Vn—Cl, Vn—Br, Vn—I, Vn—ORa, and Vn—CN;
• R11 is H, methyl, ethyl, F, Cl, Br, I, CF3, CHF2, CH2F, OH, O—(C1-C4 alkyl), or NH2;
• R12 and R13 are independently H, C1-C6 alkyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl, CH2-heterocyclyl, aryl, heteroaryl, (1-3C alkyl)heteroaryl, or (CH2)n(CRxRy)C(O)NR8R9, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, CH2-heterocyclyl, heterocyclyl, aryl, heteroaryl and (1-3C alkyl)heteroaryl are optionally substituted with one or more groups independently selected from oxo, F, Cl, CF3, CN, OR8, C(═O)OR8, C(═O)NR8R9, NR8R9, C(O)(C1-C6 alkyl), C(O)-heterocycle [optionally substituted with O—(C1-C6 alkyl) or oxo], SRa, SO2Rf, SO2NRcRe, C(O)(C1-C6 alkyl)NRcRd, C(O)(C1-C6 alkyl)ORc, C(O)CH2C(O)(C1-C6 alkyl), C(═O)CHRgNHC(═O)(C1-C6 alkyl), C(═O)CH2C(═O)(C1-C6 alkyl), C1-C6 alkyl, 5-6 membered heterocycle (optionally substituted with oxo) and aryl,
• or R12 and R13 together with the atoms to which they are attached form a saturated, partially unsaturated or aromatic carbocyclic or heterocyclic ring, wherein said carbocyclic and heterocyclic rings are optionally substituted with one or more groups independently selected from C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl, aryl, heteroaryl, oxo, F, Cl, Br, I, CF3, CN, OR6, C(═O)R6, C(═O)OR6, OC(═O)R6, C(═O)NR6R7, NR6R7, NR6C(═O)R1, SR6, S(O)R6, S(O)2R6 and SO2NR6R7, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more groups independently selected from oxo, Vn—F, Vn—Cl, Vn—Br, Vn—I, V1—CF3, Vn—CN, Vn—OR8, Vn—C(═O)OR8, Vn—OC(═O)R8, Vn—C(═O)NR8R9, Vn—NR8R9, Vn—NR8C(═O)R9, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl, Vn-aryl, and Vn-heteroaryl;
• R14 is H, methyl, ethyl or OH;
• Ra and Rb are independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl, Vn-aryl, or Vn-heteroaryl, wherein said alkyl, alkenyl, alkynyl, saturated or partially unsaturated Vn-cycloalkyl, saturated or partially unsaturated Vn-heterocyclyl, Vn-aryl, and Vn-heteroaryl are optionally substituted with one or more OH;
• each Rc, Re and Rg is independently H or C1-C6 alkyl;
• Rd is H, C1-C6 alkyl or C(O)O(C1-C6 alkyl);
• Rf is C1-C6 alkyl or (C1-C6 alkyl)NH2;
• Rx is H or C1-C6 alkyl;
• Ry is H, C1-C6 alkyl, or —O(C1-C6 alkyl);
• V is alkylene having from 1 to 12 carbons, or alkenylene or alkynylene each having from 2 to 12 carbons, wherein said alkylene, alkenylene, or alkynylene are optionally substituted with one or more groups independently selected from C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, saturated and partially unsaturated C3-C6 cycloalkyl, saturated and partially unsaturated C1-C6 heterocyclyl, aryl, heteroaryl, F, Cl, Br, I, CF3, cyano, OR8, C(═O)OR8, OC(═O)R8, C(═O)NR8R9, NR8R9, (C1-C6 alkyl)NRcRe, and NR8C(═O)R9;
• and
• n is 0 or 1.