Organic Compounds
OwnerNigel Graham Cooke, Paul W. Manleyinventors
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Abstract
The invention provides a pharmaceutical combination comprising: a) at least one agent selected from Bcr-Abl, Flt-3, FAK and RAF kinase inhibitors; and b) at least one JAK kinase inhibitor and a method for treating or preventing a proliferative disease using such a combination.
Claims9
A pharmaceutical combination comprising:
- a) at least one agent selected from Bcr-Abl, Flt-3, FAK and RAF kinase inhibitors;
- and
- b) at least one subtype-selective or subtype unselective JAK kinase inhibitor.
A method for treating or preventing a proliferative disease in a subject in need thereof, comprising co-administration to said subject, e.g., concomitantly or in sequence, of a therapeutically effective amount of at least one agent selected from Bcr-Abl, Flt-3, FAK and RAF kinase inhibitors and at least one subtype-selective or subtype-unselective JAK kinase inhibitor.
(canceled)
A method for myeloma comprising administering a combination of a RAF inhibitor and a JAK kinase inhibitor wherein the RAF inhibitor is selected from:
- (4-tert-butyl-phenyl)-(4-pyridin-4-ylmethyl-isoquinolin-1-yl)-amine;
- [4,7′]biisoquinolinyl-1-yl-4-(tert-butyl-phenyl)-amine;
- (4-tert-butyl-phenyl)-(4-quinazolin-6-yl-isoquinolin-1-yl)-amine;
- [4,7′]biisoquinolinyl-1-yl-(2-tert-butyl-pyrimidin-5-yl)-amine;
- and combinations thereof, and the JAK kinase inhibitor is selected from:
- N-benzyl-3,4-dihydroxy-benzylidene-cyanoacetamide α-cyano-(3,4-dihydroxy)-]N-benzylcinnamamide (Tyrphostin AG 490);
- prodigiosin 25-C(PNU156804);
- [4-(4′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline] (WHI-P131);
- [4-(3′-bromo-4′-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline] (WHI-P154);
- [4-(3′,5′-dibromo-4′-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline] WHI-P97;
- 3-{(3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile,
- in free form or in salt form, e.g., mono-citrate (also called CP-690,550);
- and combinations thereof.
Dependencies are inferred from the claim text.