Spirocyclic Azaindole Derivatives

Spirocyclic azaindole derivatives of the Formula I,

• wherein
• A denotes N or CR7-10, wherein at least once and at most twice A denotes N
• W denotes NR4
• X denotes NR17, O or S
• R1 and R2 independently of one another denote H;
• C1-5-alkyl, in each case saturated or unsaturated, branched or unbranched, monosubstituted or polysubstituted or unsubstituted;
• C3-8-cycloalkyl, in each case monosubstituted or polysubstituted or unsubstituted;
• or denote aryl, C3-8-cycloalkyl or heteroaryl bonded via C1-3-alkyl, in each case monosubstituted or polysubstituted or unsubstituted;
• or the radicals R1 and R2 together denote CH2CH2OCH2CH2, CH2CH2NR10CH2CH2 or (CH2)3-6,
• wherein R10 denotes H;
• C1-5-alkyl, in each case saturated or unsaturated, branched or unbranched, monosubstituted or polysubstituted or unsubstituted;
• C3-8-cycloalkyl, in each case monosubstituted or polysubstituted or unsubstituted;
• aryl or heteroaryl, in each case monosubstituted or polysubstituted or unsubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl bonded via C1-3-alkyl, in each case monosubstituted or polysubstituted or unsubstituted;
• C(O)phenyl, C(O)heteroaryl, C(O)C1-5-alkyl, in each case substituted or unsubstituted;
• R3 denotes C1-8-alkyl, in each case saturated or unsaturated, branched or unbranched, monosubstituted or polysubstituted or unsubstituted;
• C3-8-cycloalkyl, in each case monosubstituted or polysubstituted or unsubstituted;
• aryl or heteroaryl, in each case unsubstituted or monosubstituted or polysubstituted;
• aryl, heteroaryl or C3-8-cycloalkyl bonded via a C1-3-alkyl group, in each case unsubstituted or monosubstituted or polysubstituted;
• R4 denotes H;
• C1-5-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or monosubstituted or polysubstituted;
• aryl or heteroaryl, in each case substituted or unsubstituted;
• aryl, heteroaryl or cycloalkyl bonded via a C1-3-alkyl group, in each case monosubstituted or polysubstituted or unsubstituted;
• COR12;
• SO2R12,
• wherein R12 denotes H;
• C1-5-alkyl, in each case saturated or unsaturated, branched or unbranched, monosubstituted or polysubstituted or unsubstituted;
• C3-8-cycloalkyl, in each case saturated or unsaturated, monosubstituted or polysubstituted or unsubstituted;
• aryl or heteroaryl, in each case monosubstituted or polysubstituted or unsubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl bonded via C1-3-alkyl, in each case monosubstituted or polysubstituted or unsubstituted;
• OR13;
• NR14R15;
• R5 denotes ═O;
• H;
• COOR13, CONR13, OR13;
• C1-5-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or monosubstituted or polysubstituted;
• C3-8-cycloalkyl, saturated or unsaturated, unsubstituted or monosubstituted or polysubstituted;
• aryl or heteroaryl, unsubstituted or monosubstituted or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl bonded via C1-3-alkyl, unsubstituted or monosubstituted or polysubstituted;
• R6 denotes H;
• F, Cl, NO2, CF3, OR3, SR13, SO2R13, SO2OR13, CN, COOR13, NR14R15;
• C1-5-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or monosubstituted or polysubstituted;
• C3-8-cycloalkyl, saturated or unsaturated, unsubstituted or monosubstituted or polysubstituted;
• aryl or heteroaryl, unsubstituted or monosubstituted or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl bonded via C1-3-alkyl, unsubstituted or monosubstituted or polysubstituted;
• or R5 and R6 together denote (CH2)n where n=2, 3, 4, 5 or 6, wherein individual hydrogen atoms can also be replaced by F, Cl, Br, I, NO2, CF3, OR13, CN or C1-5-alkyl;
• R7, R8, R9 and R10 independently of one another denote
• H, F, Cl, Br, I, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, CN, COOR13, NR14R15;
• C1-5-alkyl, C3-8-cycloalkyl, unsubstituted or monosubstituted or polysubstituted;
• aryl or heteroaryl, unsubstituted or monosubstituted or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl bonded via C1-3-alkyl, unsubstituted or monosubstituted or polysubstituted;
• wherein R13 denotes H;
• C1-5-alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted or monosubstituted or polysubstituted;
• C3-8-cycloalkyl, in each case saturated or unsaturated, unsubstituted or monosubstituted or polysubstituted;
• aryl or heteroaryl, unsubstituted or monosubstituted or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl bonded via C1-3-alkyl, unsubstituted or monosubstituted or polysubstituted;
• R14 and R15 independently of one another denote H;
• C1-5-alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted or monosubstituted or polysubstituted;
• or C3-8-cycloalkyl, in each case saturated or unsaturated, unsubstituted or monosubstituted or polysubstituted;
• aryl or heteroaryl, unsubstituted or monosubstituted or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl bonded via
• C1-3-alkyl, unsubstituted or monosubstituted or polysubstituted;
• or R14 and R15 together denote CH2CH2OCH2CH2, CH2CH2NR16CH2CH2 or (CH2)3-6,
• wherein R16 denotes H;
• C1-5-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or monosubstituted or polysubstituted;
• R17 denotes H;
• C1-8-alkyl, saturated or unsaturated, branched or unbranched;
• COR12 or SO2R12
• in the form of the racemate;
• in the form of the enantiomers, diastereomers, mixtures of the enantiomers or diastereomers, or of an individual enantiomer or diastereomer;
• in the form of the bases and/or salts of physiologically compatible acids.