1,2-di(cyclic group)substituted benzene derivative

A compound represented by the following general formula (I), a salt thereof or a hydrate of the foregoing:

• wherein R10 represents 5- to 10-membered cycloalkyl optionally substituted with a substituent selected from Group A1 or 5- to 10-membered cycloalkenyl optionally substituted with a substituent selected from Group A1,
• R30, R31 and R32 may be the same or different and each represents hydrogen, hydroxyl, halogen, cyano, carboxyl, C1-6 alkyl, C1-6 alkoxy or C2-7 alkoxycarbonyl, or
• two of R30, R31 and R32 bond together to form oxo (═O) or methylene (—CH2—) and the other represents hydrogen, hydroxyl, halogen, cyano, carboxyl, C1-6 alkyl, C1-6 alkoxy or C2-7 alkoxycarbonyl,
• R40 represents C1-10 alkyl optionally substituted with a substituent selected from Group
• D1, 3- to 8-membered cycloalkyl optionally substituted with a substituent selected from Group E1, a 4- to 8-membered heterocyclic group optionally substituted with a substituent selected from Group E1, C2-7 alkenyl optionally substituted with a substituent selected from Group F1, C2-7 alkynyl optionally substituted with a substituent selected from Group F1, C2-7 alkylcarbonyl optionally substituted with a substituent selected from Group G1, mono(C1-6 alkyl)aminocarbonyl, 4- to 8-membered heterocyclic carbonyl, C2-7 alkoxycarbonyl or C1-6 alkylsulfonyl,
• n represents an integer of 0, 1 or 2,
• X1 represents CH or nitrogen, and
• R20, R21, R22 and R23 may be the same or different and each represents hydrogen, hydroxyl, halogen, nitro, cyano, carboxyl, C1-6 alkylthio optionally substituted with a substituent selected from Group F1, C2-7 alkoxycarbonyl, phenoxy, —SO3H, C1-6 alkyl optionally substituted with a substituent selected from Group W1, C1-6 alkyl optionally substituted with a substituent selected from Group K1, C1-6 alkoxy optionally substituted with a substituent selected from Group W1, a 4- to 8-membered heterocyclic group optionally substituted with a substituent selected from Group W1, a 4- to 8-membered heterocyclic group optionally substituted with a substituent selected from Group V1, a 5- to 10-membered heteroaryl ring group optionally substituted with a substituent selected from Group W1, a 6- to 10-membered aryl ring group optionally substituted with a substituent selected from Group W1, C2-7 alkenyl optionally substituted with a substituent selected from Group W1, C2-7 alkynyl optionally substituted with a substituent selected from Group W1, 3- to 8-membered cycloalkyl optionally substituted with a substituent selected from Group W1, 5- to 8-membered cycloalkenyl optionally substituted with a substituent selected from Group W1, —NR1XR2X, —CO—R1X, CO—NR1XR2X, NR1X—CO—R2X—SO2—R3X or —O—SO2—R3X,
• wherein R1X and R2X may be the same or different and each represents hydrogen, C1-6 alkyl optionally substituted with a substituent selected from Group U1 or a 4- to 8-membered heterocyclic group, and
• R1X represents C1-6 alkyl optionally substituted with a substituent selected from Group F1;
• or
• (i) R20 and R21, (ii) R21 and R22 or (iii) R22 and R23 bond together to form a ring selected from Group Z1,
• wherein Group A1 consists of hydroxyl, halogen, cyano, C1-6 alkoxy, phenyl optionally substituted with a substituent selected from Group C1, C1-6 alkyl, C1-6 haloalkyl and C2-7 alkylene where C2-7 alkylene is permissible only in the case that a spiro union is formed together with the substituted 5- to 10-membered cycloalkyl or the substituted 5- to 10-membered cycloalkenyl,
• Group C1 consists of cyano, halogen, C1-6 alkyl and C1-6 alkoxy, Group D1 consists of hydroxyl, halogen, cyano, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl, mono. (C1-6 alkyl)amino, di(C1-6 alkyl)amino, C2-7 alkylcarbonylamino, 3- to 8-membered cycloalkyl optionally substituted with a substituent selected from Group H1, C2-7 alkoxycarbonyl, carboxyl, a 4- to 8-membered heterocyclic group, a 5- to 10-membered heteroaryl ring group, a 6- to 10-membered aryl ring group, C2-7 alkylcarbonyl, 6- to 10-membered aryl ring carbonyl, aminocarbonyl, mono(C1-6 alkyl)aminocarbonyl optionally substituted with halogen, mono(3- to 8-membered cycloalkyl)aminocarbonyl, mono(C2-7 alkoxyalkyl)aminocarbonyl, di(C1-6 alkyl)aminocarbonyl, mono(5- to 10-membered heteroaryl ring)aminocarbonyl, 4- to 8-membered heterocyclic carbonyl optionally substituted with C1-6 alkyl, and 5- to 10-membered heteroaryl ring carbonyl,
• Group E1 consists of halogen, C1-6 alkoxy, oxo (═O) and C1-6 alkyl,
• Group F1 consists of halogen and C1-6 alkoxy,
• Group G1 consists of 3- to 8-membered cycloalkyl,
• Group H1 consists of hydroxyl, C1-6 haloalkyl, C1-6 alkyl, C2-7 alkoxyalkyl, mono(C1-6 alkyl)aminocarbonyl, di(C1-6 alkyl)aminocarbonyl, C2-7 alkoxycarbonyl, carboxyl and C2-7 cyanoalkyl,
• Group W1 consists of halogen, hydroxyl, cyano, carboxyl, C1-6 alkyl, C2-7 alkoxyalkyl, C1-6 alkoxy optionally substituted with a substituent selected from Group T1, phenoxy, C2-7 alkoxycarbonyl, C2-7 alkylcarbonyl, —NR6XR7X and —CO—NR6XR7X wherein R6X and R7X may be the same or different and each represents hydrogen or C1-6 alkyl,
• Group T1 consists of C1-6 alkoxy, carboxyl, C2-7 alkoxycarbonyl and —CON4XNR5X wherein R4X and R5X may be the same or different and each represents hydrogen or C1-6 alkyl,
• Group V1 consists of oxo (═O) and ethylenedioxy (—O—CH2CH2—O—) where ethylenedioxy is permissible only in the case that a spiro union is formed together with the substituted 4-;
• to 8-membered heterocyclic group,
• Group K1 consists of a 4- to 8-membered heterocyclic group,
• Group U1 consists of carboxyl, C1-6 alkoxy, C2-7 alkoxycarbonyl, halogen, a 6- to 10-membered aryl ring group and —CO—NR8xR9x wherein R8x and R9x may be the same or different and each represents hydrogen or C1-6 alkyl, and
• Group Z1 consists of
• wherein R1Z represents hydrogen, C1-6 alkyl or benzyl,
• with the proviso that a compound represented by the following formula:
• is excepted.