3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents

A compound of formula I:

• wherein, independently for each occurrence,
• A is a monocyclic ring of 4-7 atoms containing 0-2 heteroatoms, a bicyclic ring of 8-12 atoms containing 0-4 heteroatoms or a tricyclic ring of 8-12 atoms containing 0-6 heteroatoms wherein the rings are independently aliphatic, aromatic, heteroaryl or heterocyclic in nature, the heteroatoms are selected from N, S or O and the rings are optionally substituted with one or more groups selected from C1-4 alkyl, OR″, CN, OCF3, F, Cl, Br, I;
• wherein R″ is H, alkyl, aralkyl, or heteroaralkyl;
• R is
• wherein, independently for each occurrence,
• R1 is OH or —O(CH2)n—Ar;
• wherein,
• n is an integer from 1 to 6 inclusive, and
• Ar is aryl or heteroaryl;
• R2 is H or —C(O)R3;
• R3 is H, alkyl, or aryl;
• R4 is OH or N(R3)2;
• the two R5 taken together form a spirocyloalkane, a spiroaryl, or a spiroheterocycloalkane;
• R6 is H, OH, alkyl, or aryl;
• R7 is alkyl, aryl, cycloalkane, or heterocycloalkane;
• M is H or OH, or two M taken together form O or N(R3);
• provided that when R is
• R′ is (R)-Me;
• and
• pharmaceutically acceptable salts thereof.