Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases

A compound of formula (II) or salt thereof

• or a compound of formula (II)′ or salt thereof
• wherein
• B represents the group
• wherein
• ring D, together with the two benzene carbon atoms to which it is fused, is a 5- or 6-membered, non-aromatic ring containing one or two ring-oxygen atoms, and optionally containing a carbon-carbon double bond between two ring carbon atoms other than said benzene carbon atoms, ring D being optionally substituted with one or more substituents independently selected from C1-C6 alkyl, C3-C6 cycloalkyl, or phenyl (said phenyl being optionally substituted with one or more substituents independently selected from halogen, hydroxyl or C1-C4 alkoxy);
• and additionally wherein when ring D is a 5-membered, non-aromatic ring containing two ring-oxygen atoms that are 1,3 disposed, ring D may be optionally substituted with group E, wherein group E together with a single carbon atom on ring D, represents a 4- to 8-membered cycloalkyl ring, such that group E forms a spiro structure with ring D;
• each R represents a group independently selected from halogen or C1-C4 alkyl;
• and
• n is 0, 1 or 2;
• w, x, v and z are independently 1, 2 or 3;
• A represents a group selected from phenyl, a 5- or 6-membered heteroaromatic ring containing at least one ring heteroatom independently selected from nitrogen, oxygen or sulphur, or pyridine-N-oxide, each group being optionally substituted with one or more substituents independently selected from hydroxyl, —CN, halogen, oxo (═O), C1-C6 aminoalkyl, C1-C6 alkylamino, C1-C6 alkyl, N,N-di(C1-C6)alkylamino-C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylcarbonyl, —NR1R2, —C(O)—NR3R4, —C1-C6 alkylenyl-C(O)—NR3R4, —C1-C4 alkyl-C(O)—NR5R6, —NHSO2—R7, —NHC(O)R8, —SO2NH2, carboxyl, carboxyl-C1-C6 alkyl, C1-C6 alkoxycarbonyl, C1-C4 alkoxycarbonyl-C1-C4 alkyl, C3-C6 cycloalkylamino, phenyl, pyridyl (said phenyl and pyridyl being optionally further substituted with one or more groups independently selected from halogen, hydroxyl, carboxy or C1-C4 alkyl), C1-C6 alkyl or C3-C6 cycloalkyl (said latter two C1-C6 alkyl and C3-C6cycloalkyl substituents being optionally further substituted with one or more substituents independently selected from halogen, hydroxyl, or —CN);
• or A represents a 9- or 10-membered bicyclic ring system containing one or more ring heteroatoms independently selected from nitrogen, oxygen or sulphur and which is optionally substituted with one or more substituents independently selected from hydroxyl, —CN, halogen, oxo, C1-C6 alkoxy, —NR9R10, carboxyl, or C1-C6 alkyl;
• wherein:
• R1 and R2 each independently represent a hydrogen atom, a C1-C6 alkyl, C3-C6 cycloalkyl or R1 and R2 together with the nitrogen atom to which they are attached form a hydantoin group or form a 4- to 7-membered saturated heterocycle, said heterocycle being optionally substituted with hydroxyl, C1-C4 alkoxy, or C1-C4 alkoxy-C1-C4 alkyl;
• R3 and R4 each independently represent a hydrogen atom, C1-C6 alkyl, or C1-C6 cycloalkyl, or R3 and R4 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocycle, said heterocycle being optionally substituted with aminocarbonyl;
• R5 and R6 each independently represent a hydrogen atom, C1-C6 alkyl, or C3-C6 cycloalkyl, or R5 and R6 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocycle, said heterocycle being optionally substituted with aminocarbonyl;
• R7 represents C1-C6 alkyl, or a 6-membered saturated or unsaturated heterocyclic ring, the ring containing at least one nitrogen atom, the ring being optionally substituted with one or more substituents independently selected from halogen, oxo, C1-C6 alkoxy, or C1-C6 alkyl;
• R8 represents pyridine-N-oxide optionally substituted with one or more substituents independently selected from halogen, or C1-C6 alkyl, or R8 represents C1-C6 alkyl, C1-C6 hydroxyalkyl, or a 5- or 6-membered saturated heterocyclic ring containing at least one heteroatom independently selected from nitrogen and oxygen, which ring being optionally substituted with one or more substituents independently selected from halogen, C1-C6 alkoxy, oxo, or C1-C6alkyl;
• and
• R9 and R10 each independently represent a hydrogen atom or C1-C6 alkyl;
• and P is an amine protecting group.