US 2009/0156563 A1Published application

Glucan Compositions

OwnerWerner Baschong, Sebastien Mongiat +1inventors

InventorsWerner Baschong, Sebastien Mongiat, Dietmar Ochs

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Abstract

A cosmetic or pharmaceutical composition is provided comprising: a) 0.001 to less than 0.2% by weight, based on the weight of the total composition, of a scleroglucan having a mean molecular weight of 1×106 to 12×106; b) a cosmetically or pharmaceutically acceptable carrier; and, optionally, c) lactic acid, a lactate and/or pentanediol. The composition shows advantageous effects, such as moisturization of skin or mucosa, and has an antiaging and revitalizing effect on the skin. When combined with a certain bactericide as explained in claim 1, compositions containing native polysaccharides of the glucan class in general, especially of the scleroglucan as of component a), are well suitable to reduce the number of bacteria in mucosal or oral environments and minimise adhesion, while retaining a pleasant feeling on the mucosa or gingiva. Plaque thus can be efficiently prevented or removed.

An antibacterial composition for contact with the mucosa or other tissues of the oral cavity, comprising

a) a glucan, in an amount of 0.001 to 0.2%, relative to the weight of the total composition, and
b) a bactericide selected from the group consisting of benzoic acid, its salts and esters;
propionic acid and its salts;
salicylic acid and its salts;
sorbic acid and its salts;
formaldehyde;
paraformaldehyde;
o-phenylphenol and its salts;
inorganic sulphites and hydrogen sulphites;
sodium iodate;
chlorobutanol;
4-hydroxybenzoic acid and its salts and esters;
3-acetyl-6-methylpyran-2,4(3H)-dione;
formic acid;
sodium formiate;
dibromohexamidine and its salts;
undec-10-enoic acid and salts;
hexetidine;
5-bromo-5-nitro-1,3-dioxane;
bronopol;
2,4-dichlorobenzyl alcohol;
triclocarban;
2.4.4′-trichloro-2′-hydroxy-diphenylether (Triclosan);
4-chloro-3,5-xylenol;
imidazolidinyl urea;
poly(1-hexamethylenebiguanide hydrochloride);
2-phenoxyethanol;
hexamethylenetetramine;
methenamine 3-chloroallylochloride;
1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one;
1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione;
benzyl alcohol;
1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)-2-pyridon or its monoethanolamine salt;
methyldibromoglutaronitrile;
bromochlorophen;
4-isopropyl-m-cresol;
mixture of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-methylisothiazol-3(2H)-one with magnesium chloride and magnesium nitrate;
clorophene;
2-chloroacetamide;
chlorhexidine and its digluconate, diacetate and/or dihydrochloride;
1-phenoxypropan-2-ol;
alkyl (C12-C22) trimethyl ammonium bromide and/or chloride;
4,4-dimethyl-1,3-oxizalidine;
N-(hydroxymethyl)-N-(dihydroxymethyl-1,3-dioxo-2,5-imidazolidinyl-4)-N′-(hydroxymethyl)urea;
hexamidine and its salts;
glutaraldehyde;
chlorphenesin;
sodium hydroxymethylglycinate;
benzethonium chloride;
benzalkonium chloride, bromide and/or saccharinate;
benzylhemiformal, listerine, alexidine, and essential oils including thymol, geraniol, carvacrol, citral, hinokitiol, eucalyptol, eugenol, menthol, or catechol.

48 more elements

Abstract

Claims26