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US 2009/0156559 A1Published application
2-ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
AssigneeTelik, Inc.
InventorsEdgardo Laborde, Andrew B. Kelson, Wenli Ma, Kevin T. Weber
Life of this patent
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Abstract
2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer and autoimmune diseases, alone and in combination with other therapies.
Claims13
A compound of formula A:
- or its salt,
- where each R is independently methyl, ethyl, propyl, or isopropyl, or —NR2 together is pyrrolidin-1-yl or piperidin-1-yl.
A method of preparing a compound of formula A:
- or its salt,
- where each R is independently methyl, ethyl, propyl, or isopropyl, or —NR2 together is pyrrolidin-1-yl or piperidin-1-yl;
- comprising:
- (a) oxidizing a corresponding compound of formula B:
- to the compound of formula A,
- optionally followed by one or more of:
- (b) forming a salt of a compound of formula A;
- (c) converting a salt of a compound of formula A to another salt of a compound of formula A;
- and
- (d) converting a salt of a compound of formula A to the non-salt form of the compound of formula A.
7 more elements
A compound of formula B:
- or its salt,
- where each R is independently methyl, ethyl, propyl, or isopropyl, or —NR2 together is pyrrolidin-1-yl or piperidin-1-yl.
Dependencies are inferred from the claim text.