Topical delivery of phthalocyanines

A pharmaceutically acceptable salt of a compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof

• [Pc.M] (I)
• wherein Pc is a substituted or unsubstituted phthalocyanine;
• and
• M is a diamagnetic metal ion, optionally complexed with or covalently bound to one or two axial ligands, wherein the metal ion is coordinated to the phthalocyanine moiety.

A pharmaceutically acceptable salt of a compound having a structure of formula (II) or a pharmaceutically acceptable salt thereof

• wherein M is a diamagnetic metal ion optionally complexed with or covalently bound to one or two axial ligands, wherein the metal ion is coordinated to the phthalocyanine moiety;
• and
• R1-R16 are each independently selected from hydrogen, halogen, nitro, cyano, hydroxy, thiol, amino, carboxy, aryl, heteroaryl, carbocyclyl, heterocyclyl, C1-20alkyl, C1-20alkenyl, C1-20alkynyl, C1-20alkoxy, C1-20acyl, C1-20alkylcarbonyloxy, C1-20aralkyl, C1-20hetaralkyl, C1-20carbocyclylalkyl, C1-20heterocyclylalkyl, C1-20aminoalkyl, C1-20alkylamino, C1-20thioalkyl, C1-20alkylthio, C1-20hydroxyalkyl, C1-20alkyloxycarbonyl, C1-20alkylaminocarbonyl, C1-20alkylcarbonylamino, C1-10alkyl-Z-C1-10alkyl;
• R17 is selected from hydrogen, C1-20acyl, C1-20alkyl, and C1-20aralkyl;
• and
• Z is selected from S, NR17, and O.

A pharmaceutically acceptable salt of a compound having a structure of Formula (III) or a pharmaceutically acceptable salt thereof

• wherein M is (G)aY[(OSi(CH3)2(CH2)bNc(R′)d(R″)e)fXg]p;
• Y is selected from Si, Al, Ga, Ge, or Sn;
• R′ is selected from H, CH3, C2H5, C4H9, C4H8NH, C4H8N, C4H8NCH3, C4H8S, C4H8O, C4H8Se, OC(O)CH3, OC(O), CS, CO, CSe, OH, C4H8N(CH2)3CH3, (CH2)2N(CH3)2, (CH2)nN((CH2)o(CH3))2, and an alkyl group having from 1 to 12 carbon atoms;
• R″ is selected from H, SO2CH3, (CH2)2N(CH3)2, (CH2)11CH3, C(S)NHC6H11O5, (CH2)nN((CH2)o(CH3))2, and an alkyl group having from 1 to 12 carbon atoms;
• G is selected from OH and CH3;
• X is selected from I, F, Cl, or Br;
• a is 0 or 1;
• b is an integer from 2 to 12;
• c is 0 or 1;
• d is an integer from 0 to 3;
• e is an integer from 0 to 2;
• f is 1 or 2;
• g is 0 or 1;
• n is an integer from 1 to 12;
• o is an integer from 1 to 11;
• and
• p is 1 or 2.