Compositions and methods for modulating the immune system
OwnerPatrick T. Prendergastinventor
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Abstract
The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair.
Claims41
A method for the treatment and/or prophylaxis of blood cell depletion, the method comprising:
- providing a therapeutically effective or prophylactically effective amount of oltipraz or a derivative, analogue, metabolite, prodrug or pharmaceutically acceptable salt thereof;
- and
- administering the same to a subject in need thereof.
A pharmaceutical composition for use in the treatment of blood cell depletion, the composition comprising oltipraz or a derivative, analogue, metabolite, prodrug or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent and/or carrier.
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A method for the treatment and/or prophylaxis of blood cell depletion, the method comprising:
- providing a therapeutically or prophylactically effective amount of at least one cytokinin compound;
- and
- administering the same to a subject in need thereof.
A pharmaceutical composition for use in the treatment of blood cell depletion, the composition comprising N6 isopentenyl adenosine or a derivative, analogue, metabolite, prodrug or pharmaceutically acceptable salt thereof, along with a pharmaceutically acceptable diluent and/or carrier.
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A combined pharmaceutical composition for the prevention and/or treatment and/or amelioration of a blood cell deficiency disorder, such as neutropenia, thrombocytopenia or anaemia, the composition comprising a cytokinin compound and oltipraz or a derivative or functionally equivalent analogue thereof along with at least one pharmaceutically acceptable diluent.
A method of stimulating cellular DNA repair mechanisms in a subject in advance of or following exposure of the subject to radiation, the method comprising the steps of:
- providing a therapeutically or prophylactically effective amount of oltipraz or a derivative, analogue, metabolite or salt thereof, and
- administering the composition to a subject in need of thereof.
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A pharmaceutical composition for mediating DNA repair following radiation exposure comprising oltipraz or a derivative or analogue thereof along with a pharmaceutically acceptable carrier.
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A method of treating and/or preventing radiation-induced immunosuppression, the method comprising the step of administering a therapeutically or prophylactically effective amount of N6 isopentenyl adenosine to a subject in need thereof.
Dependencies are inferred from the claim text.